The well-known androgen-regulated homeobox gene, NKX3.1, is located on the short arm of chromosome 8. It is the first known prostate epithelium-specific marker, and is a transcription factor involved in development of the testes and prostate. In addition to specifying the prostate epithelium and maintaining normal prostate secretory function, Nkx3.1 is an established marker for prostate cancer. Over the years, however, this gene has been implicated in various other cancers, and technological advances have allowed determination of its role in other cellular functions. Nkx3.1 has also been recently identified as a factor capable of replacing Oct4 in cellular reprogramming. This review highlights the role of this tumor suppressor and briefly describes its functions, ranging from prostate development to maintenance of stemness and cellular reprogramming.

中文翻译：

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Nkx3.1在癌症和干性中的作用。

著名的雄激素调节同源盒基因NKX3.1，位于8号染色体的短臂上。它是第一个已知的前列腺上皮特异性标志物，是参与睾丸和前列腺发育的转录因子。除了指定前列腺上皮和维持正常的前列腺分泌功能外，Nkx3.1是已建立的前列腺癌标记物。然而，多年来，该基因已经牵涉到其他多种癌症中，并且技术的进步已经确定了它在其他细胞功能中的作用。Nkx3.1最近也被确定为能够在细胞重编程中替代Oct4的因素。这篇综述着重介绍了这种抑癌剂的作用，并简要介绍了其功能，从前列腺发育到维持干性和细胞重编程。