Induced pluripotent stem cells (iPSCs) are usually generated by reprogramming differentiated cells throughthe introduction of specific transcription factors, but this is a difficult and inefficient process. Valproic acid (VPA) is a histone deacetylase inhibitor that significantly improves the efficiency of iPSC generation. But its role and mechanism are still unclear.

中文翻译：

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丙戊酸通过促进内源基因c-Myc的表达和血管生成过程来增强双峰驼细胞的重编程。

诱导多能干细胞（iPSC）通常是通过引入特定转录因子对分化的细胞进行重编程而生成的，但这是一个困难而效率低下的过程。丙戊酸（VPA）是一种组蛋白脱乙酰基酶抑制剂，可显着提高iPSC产生的效率。但是其作用和机制尚不清楚。