COVID-19 is an acute respiratory distress syndrome and is often accompanied by gastrointestinal symptoms. The SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swabs of COVID-19 patients. The gut microbiota is important for an effective immune response as it ensures that unfavorable immune reactions in lungs and other vital organs are regulated. The human gut-lung microbiota interplay provides a framework for therapies in the treatment and management of several pulmonary diseases and infections. Here, we have collated data from COVID-19 studies, which suggest that bacterial co-infections as well as the gut-lung cross talk may be important players in COVID-19 disease prognosis. Our analyses suggests a role of gut microbiome in pathogen infections as well as in an array of excessive immune reactions during and post COVID-19 infection recovery period.

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COVID-19 的严重程度与肠道微生物组之间的相互作用：细菌合并感染的影响？

COVID-19 是一种急性呼吸窘迫综合征，常伴有胃肠道症状。SARS-CoV-2 不仅在鼻咽和鼻中部拭子中被发现，而且还在 COVID-19 患者的粪便和直肠拭子中被发现。肠道微生物群对于有效的免疫反应很重要，因为它确保调节肺部和其他重要器官的不利免疫反应。人类肠道-肺微生物群的相互作用为治疗和管理多种肺部疾病和感染提供了一个治疗框架。在这里，我们整理了 COVID-19 研究的数据，这些数据表明细菌合并感染以及肠肺串扰可能是 COVID-19 疾病预后的重要因素。