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Molecular characteristics of Neisseria meningitidis in Qatar
Scientific Reports ( IF 3.8 ) Pub Date : 2021-02-26 , DOI: 10.1038/s41598-021-84262-1
Manal Mahmoud Hamed 1 , Fayaz Ahmad Mir 1 , Emad Bashier Ibrahim Elmagboul 1 , Abdullatif Al-Khal 1 , Muna A Rahman S Al Maslamani 1 , Anand Sarwottam Deshmukh 1 , Hamad Eid Al-Romaihi 2 , Mohd Ahmed M Sharif Janahi 1 , Fatma Ben Abid 1 , Adila Shaukat Ali Kashaf 1 , Gulab Sher 1 , Vinod Kumar Gupta 1 , Godwin J Wilson 1 , Junais Kadalayi 1 , Sanjay H Doiphode 1
Affiliation  

The aim of the current study is to review the molecular characteristics of Neisseria meningitidis (N. meningitidis) in Hamad Medical Corporation, which is the provider of secondary and tertiary care in the state of Qatar. A total of 39 isolates of N. meningitidis from the period of 2013 to 2018 were revived and identified by Vitek, and susceptibility on the basis of the E test was retrieved from the patient’s files. The revived isolates were subjected to multilocus sequence typing. The most common serogroup (19) of N. meningitidis was W135, of which 12 were isolated from blood and CSF. ST-11 was the most predominant ST clonal complex causing N. meningitidis cases (61.53%). Clonal complex ST-41/44 was the second most observed complex (3, 2 of which were related to serogroup B). The most frequent sequence type was 9596 (8 isolates). Determining the molecular pattern of N. meningitidis in Qatar is helpful for understanding the strains circulating in Qatar, and the study of the resistance trend of such strains may be very helpful for empirical treatment of future patients.



中文翻译:

卡塔尔脑膜炎奈瑟菌的分子特征

本研究的目的是回顾哈马德医疗公司(卡塔尔州二级和三级医疗保健提供者)的脑膜炎奈瑟菌脑膜炎奈瑟菌)的分子特征。Vitek对2013年至2018年期间共有39株脑膜炎奈瑟菌进行了复苏和鉴定,并从患者档案中检索了基于E测试的敏感性。对复活的分离株进行多位点序列分型。脑膜炎奈瑟菌最常见的血清群 (19)是 W135,其中 12 个是从血液和脑脊液中分离出来的。ST-11 是导致脑膜炎奈瑟菌的最主要的 ST 克隆复合体例(61.53%)。克隆复合体 ST-41/44 是第二多观察到的复合体(3 个,其中 2 个与血清群 B 相关)。最常见的序列类型是 9596(8 个分离株)。确定卡塔尔脑膜炎奈瑟菌的分子模式有助于了解卡塔尔流行的菌株,研究此类菌株的耐药趋势可能对未来患者的经验性治疗很有帮助。

更新日期:2021-02-26
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