Intracranial pressure (ICP) monitoring is important in managing neurosurgical, neurological, and ophthalmological patients with open-angle glaucoma. Non-invasive two-depth transcranial Doppler (TCD) technique is used in a novel method for ICP snapshot measurement that has been previously investigated prospectively, and the results showed clinically acceptable accuracy and precision. The aim of this study was to investigate possibility of using the ophthalmic artery (OA) as a pressure sensor for continuous ICP monitoring. First, numerical modeling was done to investigate the possibility, and then a pilot clinical study was conducted to compare two-depth TCD-based non-invasive ICP monitoring data with readings from an invasive Codman ICP microsensor from patients with severe traumatic brain injury. The numerical modeling showed that the systematic error of non-invasive ICP monitoring was < 1.0 mmHg after eliminating the intraorbital and blood pressure gradient. In a clinical study, a total of 1928 paired data points were collected, and the extreme data points of measured differences between invasive and non-invasive ICP were − 3.94 and 4.68 mmHg (95% CI − 2.55 to 2.72). The total mean and SD were 0.086 ± 1.34 mmHg, and the correlation coefficient was 0.94. The results show that the OA can be used as a linear natural pressure sensor and that it could potentially be possible to monitor the ICP for up to 1 h without recalibration.

颅内压 (ICP) 监测对于管理患有开角型青光眼的神经外科、神经病学和眼科患者非常重要。非侵入性双深度经颅多普勒 (TCD) 技术用于一种新的 ICP 快照测量方法，该方法先前已进行了前瞻性研究，结果显示出临床可接受的准确度和精密度。本研究的目的是探讨使用眼动脉 (OA) 作为压力传感器进行连续 ICP 监测的可能性。首先，进行了数值建模以研究这种可能性，然后进行了一项临床试验研究，以比较基于 TCD 的两次深度无创 ICP 监测数据与来自严重创伤性脑损伤患者的侵入性 Codman ICP 微传感器的读数。数值模型表明，在消除眼眶内和血压梯度后，无创 ICP 监测的系统误差 < 1.0 mmHg。在一项临床研究中，总共收集了 1928 个配对数据点，有创和无创 ICP 之间测量差异的极端数据点为 − 3.94 和 4.68 mmHg（95% CI − 2.55 至 2.72）。总均值和 SD 为 0.086 ± 1.34 mmHg，相关系数为 0.94。结果表明，OA 可用作线性自然压力传感器，并且无需重新校准即可监测 ICP 长达 1 小时。侵入性和非侵入性 ICP 之间测量差异的极端数据点为 − 3.94 和 4.68 mmHg（95% CI − 2.55 至 2.72）。总均值和 SD 为 0.086 ± 1.34 mmHg，相关系数为 0.94。结果表明，OA 可用作线性自然压力传感器，并且无需重新校准即可监测 ICP 长达 1 小时。侵入性和非侵入性 ICP 之间测量差异的极端数据点为 − 3.94 和 4.68 mmHg（95% CI − 2.55 至 2.72）。总均值和 SD 为 0.086 ± 1.34 mmHg，相关系数为 0.94。结果表明，OA 可用作线性自然压力传感器，并且无需重新校准即可监测 ICP 长达 1 小时。