NMUPD remains a public health concern in the United States, especially among college students, and is associated with numerous poor health and economic consequences. This study aimed to quantify healthy days lost to the NMU of antidepressants, painkillers, sedatives, and stimulants using the Centers for Disease Control and Prevention’s “Healthy Days” index. A web-based survey was sent to a random, stratified sample of full-time students ages 18–24 at a large Mid-Atlantic university (N = 494). Healthy Days were calculated among demographics and for users and non-users of each prescription drug class by adding the number of poor physical and mental health days in the 30 days and subtracting the total from 30. Females reported significantly (P < .0001) fewer healthy days (N = 208) compared with males (N = 265). Significant healthy days differences were also detected between individuals who reported the NMU of antidepressants (P < .001) compared to those who did not for both males and females and for NMU of any drug (P < .01) for females only, but not for painkillers, sedatives, or stimulants. Based on our results we estimate, on average, females report 57 fewer healthy days per year than males. Furthermore, we estimate females lose an additional 34 days each year owing to the NMU of any drug and an additional 62 days for the NMU antidepressants. For males engaged in the NMU of antidepressants, we estimate the loss of 82 days each year. Results indicate significant impairment for the NMU of antidepressants and for the NMU of any drug, representing a critical barrier toward reaching Healthy People 2030 goals.

NMUPD在美国，尤其是在大学生中，仍然是一个公共卫生问题，并且与许多不良的健康和经济后果相关。这项研究旨在使用疾病控制与预防中心的“健康天数”指数来量化因抗抑郁药，止痛药，镇静剂和兴奋剂的NMU而损失的健康天数。在大型中大西洋大学（N  = 494）中，将基于网络的调查发送给年龄在18至24岁的全日制学生的随机分层样本。通过将30天中身体和精神健康状况较差的天数加上30天中的总数减去，在人口统计数据中针对每种处方药类别的使用者和非使用者计算“健康日”。女性报告的 人数显着减少（P <.0001）健康日（ñ = 208），而男性（N  = 265）。是谁报道的抗抑郁药的NMU（个体之间也发现显著健康日差P 相比，谁没有对男性和女性以及任何药物的NMU <0.001）（P <.01）仅适用于女性，但不适用于止痛药，镇静剂或兴奋剂。根据我们的结果，我们估计女性平均每年报告的健康天数比男性少57天。此外，我们估计女性由于NMU的任何药物而每年损失的额外天数为34天，而NMU抗抑郁药的损失则为62天。对于从事抗抑郁药NMU的男性，我们估计每年损失82天。结果表明，抗抑郁药的NMU和任何药物的NMU均受到严重损害，这是实现“健康人2030”目标的关键障碍。