Abstract

Objective

In the present study we evaluated the incremental contribution of executive cognition (EC) subprocesses to antiretroviral medication adherence.

Method

A comprehensive EC test battery assessing updating/working memory, mental flexibility, and inhibitory control, along with measures assessing non-executive cognitive functions were completed by 100 individuals with HIV. Medication adherence was determined via a visual analogue self-report scale and the Medication Adherence Questionnaire. Potential predictors, including demographic and clinical characteristics and neuropsychological performances on EC and other cognitive tasks were regressed to medication adherence. Predictive variables related to executive processes were added in the final block of the hierarchical regression model in order to assess their incremental predictive ability on medication adherence.

Results

23% of the variance in the visual analogue scale was explained by treatment complexity, memory and EC performance. A measure of inhibitory control, in particular, predicted self-reported medication adherence above and beyond demographic, clinical and other cognitive factors.

Conclusions

The contribution of EC to self-reported medication adherence in young seropositive adults was limited, but inhibitory control was associated with proper medication management above and beyond demographic, clinical and other cognitive functions.

中文翻译：

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抑制性控制与没有合并症的年轻 HIV 患者的药物依从性相关

摘要

客观的

在本研究中，我们评估了执行认知 (EC) 子过程对抗逆转录病毒药物依从性的增量贡献。

方法

100 名 HIV 感染者完成了评估更新/工作记忆、心理灵活性和抑制控制的综合 EC 测试组合，以及评估非执行认知功能的措施。通过视觉模拟自我报告量表和药物依从性问卷确定药物依从性。潜在的预测因素，包括人口统计学和临床​​特征以及 EC 和其他认知任务的神经心理学表现，都回归到药物依从性。与执行过程相关的预测变量被添加到分层回归模型的最后一个块中，以评估它们对药物依从性的增量预测能力。

结果

视觉模拟量表中 23% 的差异可以通过治疗复杂性、记忆力和 EC 性能来解释。一种抑制控制的测量，特别是预测自我报告的药物依从性，超出人口统计学、临床和其他认知因素。

结论

EC 对年轻血清阳性成年人自我报告的药物依从性的贡献是有限的，但抑制性控制与人口、临床和其他认知功能之外的适当药物管理相关。