Abstract

By utilizing the mixed-ligand method, two novel metal-organic frameworks (MOFs) based on Zn(II) ions as nodes with the chemical formulae of {[Zn_2.5(abta)(trz)₂(H₂O)]·3H₂O}_n (1, Htrz = 1H-1,2,4-triazole) and [Zn₃(abta)₂(bibb)₂]_n (2, bibb = 1,4-bis(benzimidazol-1-yl)-2-butene) were produced via Zn(NO₃)₂·6H₂O reacting with the 1-aminobenzene-3,4,5-tricarboxylic acid (H₃abta) in the existence of distinct nitrogen-donor co-ligands. The different N-donor ligands result in their distinct framework structures, and the compound 1 with higher solvent accessible void and large window size shows highly heterogeneous catalytic activities for Knoevenagel condensation. The treatment of Staphylococcus aureus biofilms formation during spine surgery incision infection and the related mechanism was explored at the same time. First of all, the S. aureus bacterial numbers in the infectious site was measured under compound 1 or 2 treatment. In addition to this, the relative expression levels of the genes related with S. aureus biofilms was determined with real time RT-PCR.

摘要

通过使用混合配体方法，两个基于Zn（II）离子的新型金属有机骨架（MOF）的化学式为{[Zn _2.5（abta）（trz）₂（H ₂ O）]·3H ₂ O} _n（1，Htrz = 1 H -1,2,4-三唑）和[Zn ₃（abta）₂（bibb）₂ ] _n（2，bibb = 1,4-双（苯并咪唑-1-基） ）-2-丁烯）是通过Zn（NO ₃）₂ ·6H ₂ O与1-氨基苯-3,4,5-三羧酸（H ₃abta）存在不同的氮供体共配体。不同的N供体配体导致其独特的骨架结构，具有较高溶剂可及孔隙度和较大窗口尺寸的化合物1对Knoevenagel缩合反应显示出高度不均一的催化活性。同时探讨了脊柱手术切口感染中金黄色葡萄球菌生物膜形成的治疗方法及相关机制。首先，在化合物1或2处理下测量感染部位的金黄色葡萄球菌细菌数。除此之外，与金黄色葡萄球菌有关的基因的相对表达水平 生物膜通过实时RT-PCR确定。