Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI).

Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test.

Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.6 ± 3.2 (range = 1–14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 ± 323 vs. 490 ± 299 pg/mL, p = 0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve = 0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI.

Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.

目的 本研究的目的是评估可溶性触发因子对髓样细胞-1的诊断价值，作为诊断儿童尿路感染（UTI）的新型标志物。

方法 这项研究招募了30名被诊断为急性高热性尿路感染的儿科患者。纳入30例健康儿童作为对照组。收集患者和健康对照组的血样，以进行髓样细胞-1（sTREM-1）测试中的可溶性触发受体。

结果 研究组由9名男性和21名女性组成，研究人群的平均年龄为6.6±3.2岁（范围= 1-14）。UTI患者的sTREM-1水平显着高于对照组（592±323 vs. 490±299 pg / mL，p  = 0.04）。受体工作曲线分析显示，在髓样细胞-1上表达的可溶性触发受体的截断值为514 ng / mL（曲线下的面积= 0.562）。当截断值为514 pg / mL时，在髓样细胞-1上表达的可溶性触发受体对UTI的诊断灵敏度为57％，特异性为50％。

结论 本研究表明，血浆sTREM-1水平在UTI中可能升高，因此可作为诊断UTI的有用预测工具。