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Application of the metabolomics approach to the discovery of active compounds from Brazilian trees against resistant human melanoma cells
Phytochemical Analysis ( IF 3.3 ) Pub Date : 2021-02-25 , DOI: 10.1002/pca.3041
Natália Naomi Kato 1 , Vanessa Katherinne Stavis 1 , Amanda Galdi Boaretto 1 , David Tsuyoshi Hiramatsu Castro 2 , Flávio Macedo Alves 3 , Kely de Picoli Souza 2 , Edson Lucas Dos Santos 2 , Denise Brentan Silva 1 , Carlos Alexandre Carollo 1
Affiliation  

The chemical diversity of plants plays an essential role in the development of new drugs. However, new bioactive compound identification and isolation are challenging due to the complexity and time-consuming nature of the traditional process. Recently, alternative strategies have become popular, such as the statistical approach to correlate compounds with biological activities, overcoming bottlenecks in bioactive natural product research.

中文翻译:

应用代谢组学方法从巴西树木中发现抗人类黑色素瘤细胞抗性的活性化合物

植物的化学多样性在新药的开发中起着至关重要的作用。然而,由于传统过程的复杂性和耗时性,新的生物活性化合物的鉴定和分离具有挑战性。最近,替代策略变得流行,例如将化合物与生物活性相关联的统计方法,克服了生物活性天然产物研究中的瓶颈。
更新日期:2021-02-25
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