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Theoretical investigation of optical properties of optimal architectures of magnetoplasmonic nanoparticles in human tissue for potential applications in photothermal therapy
Optical Materials ( IF 3.8 ) Pub Date : 2021-02-25 , DOI: 10.1016/j.optmat.2021.110946
M. Hadded , A. Hmima , T. Maurer , A. Chehaidar , J. Plain

The absorption and scattering efficiencies of light by a single magnetoplasmonic nanoparticle, based on magnetite and gold, embedded in human tissue are analyzed theoretically in the framework of Finite-Difference-Time-Domain method and Lorenz-Mie theory. We consider separately three different architectures for the magnetoplasmonic nanoparticle: rectangular three-layer gold/magnetite/gold nanobar, circular three-layer gold/magnetite/gold nanoring and magnetite/gold core/shell nanosphere. We address the influence of particle sizes and magnetite-layer and gold-layer thicknesses on the optical response of such nanostructures. Particular attention is paid to the effectiveness of these designed nanostructures in photothermal therapy. Our simulation shows that these hybrid nanostructures support the famous localized surface plasmon resonance mode of gold, which manifests itself in the absorption spectrum by an intense peak whose spectral position can be adjusted to be in the first and second NIR-biological windows. The magnitude of the resonant absorption peak as well as that of the corresponding scattering peak vary from one nanostructure to another and, for the same nanostructure, change with its characteristic sizes. The three-layer nanobars as well as the three-layer nanorings can support significant absorption accompanied by significant scattering of light into both NIR-biological windows. For core/shell nanospheres, the low scattering efficiency of light within the second NIR-biological window, together with their large sizes, limit the usefulness of these nanostructures in photothermal therapy operating in the first NIR-biological window only.



中文翻译:

在人体组织中磁等离子体纳米粒子的最佳结构的光学性质的理论研究在光热疗法中的潜在应用

在有限差分-时域法和洛伦兹-米氏理论的框架下,从理论上分析了嵌入在人体组织中的基于磁铁矿和金的单个磁等离子体纳米粒子对光的吸收和散射效率。我们分别考虑三种不同的磁等离子体纳米粒子的结构:矩形三层金/磁铁矿/金纳米棒,圆形三层金/磁铁矿/金纳米环和磁铁矿/金核/壳纳米球。我们解决了粒径,磁铁矿层和金层厚度对此类纳米结构的光学响应的​​影响。特别注意这些设计的纳米结构在光热疗法中的有效性。我们的模拟表明,这些杂化纳米结构支持着名的金的局部表面等离振子共振模式,该模式在吸收光谱中通过一个强峰表现出来,该峰的光谱位置可以调节到第一和第二近红外生物窗口中。共振吸收峰的大小以及相应的散射峰的大小从一个纳米结构到另一个纳米结构都变化,并且对于相同的纳米结构,随其特征尺寸而变化。三层纳米棒以及三层纳米环可以支持显着的吸收,并伴随着光显着散射到两个NIR生物窗口中。对于核/壳纳米球,第二近红外生物窗口内光的低散射效率以及它们的大尺寸,

更新日期:2021-02-26
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