Titanium dioxide (TiO₂) is a widely used biomaterial. It is a great challenge to confer antibacterial and antithrombotic properties to TiO₂ while maintaining its cell affinity. Here, we developed a new strategy to achieve the above goal by comprehensively controlling the chemical cues and geometrical cues of the surface of TiO₂. Using colloidal etching technology and UV irradiation treatment, we obtained the photofunctionalized nano-micro-honeycomb structured TiO₂. The honeycomb structured increased the photocatalytic activity of TiO₂, which endowed TiO₂ with photo-induced superhydrophilicity to inhibit bacterial adhesion. The high photocatalytic activity also induced the strong photocatalytic oxidation of TiO₂ surface organic adsorbates to suppress fibrinogen and platelet attachment. In addition, owing to the micropore trapping-isolation effect on the bacteria and the nano-frames' contact guidance effect on the growth and spreading of platelet pseudopods, the honeycomb structure also shows a considerable inhibiting effect on bacterial and platelet adhesion. Therefore, due to the controlled chemical and geometrical cues' synergistic effect, the photo-functionalized TiO₂ honeycomb structure shows excellent bacterial-adhesion resistance and antithrombotic properties. More importantly, the photo-functionalized TiO₂ honeycomb did not inhibit the adhesion and growth of endothelial cells (ECs) after culturing for 3 d, indicating a good cell affinity that the traditional antifouling surfaces do not possess.

二氧化钛（TiO ₂）是一种广泛使用的生物材料。在保持其细胞亲和力的同时赋予TiO ₂抗菌和抗血栓形成特性是一个巨大的挑战。在这里，我们开发了一种通过全面控制TiO ₂表面的化学线索和几何线索来实现上述目标的新策略。使用胶体蚀刻技术和紫外线辐射处理，我们获得了光功能化的纳米微蜂窝结构的TiO ₂。蜂窝状结构提高了TiO ₂的光催化活性，赋予了TiO ₂具有光诱导的超亲水性，可抑制细菌粘附。高的光催化活性还诱导了TiO ₂表面有机吸附物的强光催化氧化，从而抑制了纤维蛋白原和血小板的附着。此外，由于微孔对细菌的捕获-隔离作用以及纳米框架对血小板假足的生长和扩散的接触引导作用，蜂窝结构还显示出对细菌和血小板粘附的显着抑制作用。因此，由于受控制的化学和几何线索的协同作用，光功能化的TiO ₂蜂窝结构显示出优异的抗细菌粘附性和抗血栓性。更重要的是，光功能化的TiO ₂ 蜂窝细胞培养3 d后不抑制内皮细胞（ECs）的粘附和生长，这表明传统的防污表面不具备良好的细胞亲和力。