This study was aimed at reconstructing the exposure to bisphenol (BPA) of 60 pregnant women from the EXHES-Spain cohort. A biomonitoring study was conducted by determining BPA levels in urine samples over the three trimesters of pregnancy. Moreover, the correlations between BPA levels and the role of different potential exposure sources, with special emphasis on the dietary intake, were also studied. Urine samples were subjected to dispersive liquid-liquid microextraction and the subsequent analysis via gas chromatography-mass spectrometry. BPA was detected in 76% of the urine samples. A significant decrease of urinary BPA levels was observed along pregnancy, as mean concentrations of creatinine-adjusted BPA were 4.64, 4.84 and 2.51 μg/g in the first, second and third trimester, respectively. This decrease was essentially associated with changes in the dietary habits of the pregnant women, including a lower intake of canned food and drinks. However, the potential role of other pregnancy-related biochemical or physiological factors should not be disregarded. Very interestingly, significant differences in urine BPA levels were found according to the fruit consumption pattern, as women who ate more citrus fruits showed lower BPA concentrations in urine. The reconstructed exposure to BPA was estimated in 0.072, 0.069 and 0.038 μg BPA/kg of body weight/day in the first, second and third trimesters, respectively. These values are far below the temporary tolerable daily intake (t-TDI) established by the EFSA.

这项研究旨在重建来自EXHES-西班牙队列的60名孕妇的双酚（BPA）暴露。通过确定怀孕三个月期间尿液样本中的BPA水平进行了生物监测研究。此外，还研究了BPA水平与不同潜在暴露源的作用之间的相关性，其中特别着重于饮食摄入。对尿液样品进行分散液-液微萃取，然后通过气相色谱-质谱法进行分析。在76％的尿液样本中检测到了BPA。妊娠期间尿液中BPA含量显着下降，因为在孕早期，孕中期和孕晚期分别进行肌酐调整的BPA的平均浓度分别为4.64、4.84和2.51μg/ g。这种减少基本上与孕妇饮食习惯的改变有关，包括罐头食品和饮料的摄入减少。但是，不应忽略其他与妊娠相关的生化或生理因素的潜在作用。非常有趣的是，根据吃水果的方式，发现尿液中BPA含量存在显着差异，因为吃更多柑橘类水果的妇女尿液中BPA浓度较低。在孕早期，孕中期和孕中期，重构的BPA暴露量分别为0.072、0.069和0.038μgBPA / kg体重/天。这些值远低于欧洲食品安全局（EFSA）设定的临时每日允许摄入量（t-TDI）。其他与妊娠有关的生化或生理因素的潜在作用不容忽视。非常有趣的是，根据吃水果的方式，发现尿液中BPA含量存在显着差异，因为吃更多柑橘类水果的妇女尿液中BPA浓度较低。在孕早期，孕中期和孕中期，重构的BPA暴露量分别为0.072、0.069和0.038μgBPA / kg体重/天。这些值远低于欧洲食品安全局（EFSA）设定的临时每日允许摄入量（t-TDI）。其他与妊娠有关的生化或生理因素的潜在作用不容忽视。非常有趣的是，根据水果的摄入方式，发现尿液中BPA含量存在显着差异，因为吃了更多柑橘类水果的妇女尿液中BPA浓度较低。在孕早期，孕中期和孕中期，重构的BPA暴露量分别为0.072、0.069和0.038μgBPA / kg体重/天。这些值远低于欧洲食品安全局（EFSA）设定的临时每日允许摄入量（t-TDI）。在孕早期，孕中期和孕中期，重构的BPA暴露量分别为0.072、0.069和0.038μgBPA / kg体重/天。这些值远低于欧洲食品安全局（EFSA）设定的临时每日允许摄入量（t-TDI）。在孕早期，孕中期和孕中期，重构的BPA暴露量分别为0.072、0.069和0.038μgBPA / kg体重/天。这些值远低于欧洲食品安全局（EFSA）设定的临时每日允许摄入量（t-TDI）。