Aquaculture and farming industries have been seriously threatened by the illegal use of antibiotics as feed-additives to benefit the animal growth. Although various conventional chemical sensing approaches have been widely explored for the trace-level detection of antibiotics, effective and accurate monitoring techniques are still highly demanded. Herein, we propose a novel surface-enhanced Raman scattering (SERS) substrate with the heterogeneous integration of silver nanoparticles (Ag NPs) on silver vanadate nanorods (β-AgVO₃ NRs) for the ultrasensitive detection of popular antibiotic, chloramphenicol (CAP). The photochemical decoration of Ag NPs on the surface of β-AgVO₃ NRs remarkably enhances the Raman signal intensity of CAP molecules by the synergistic action of the mechanisms of electromagnetic and chemical enhancement. The structural features of Ag-NPs@β-AgVO₃-NRs favor the formation of hotspots at the interface between NPs and NRs by the enhanced surface area and numerous active sites for the interaction with CAP molecules. The SERS measurement of CAP molecules on the Ag-NPs@β-AgVO₃-NRs shows a trace-level limit of detection (10^-10 M), high uniformity (5.29%), good reproducibility (3.89%), and high analytical enhancement factor (2.05×10⁸). The proposed SERS substrate possesses excellent detection ability in monitoring real samples like tap water, milk and eye drops.

水产养殖和养殖业受到非法使用抗生素作为饲料添加剂的严重威胁，从而使动物的生长受益。尽管已经广泛探索了各种常规化学传感方法来检测抗生素的痕量水平，但仍对有效和准确的监测技术仍然有很高的要求。在此，我们提出了一种新颖的表面增强拉曼散射（SERS）基材与钒酸银纳米棒异质整合银纳米颗粒（银纳米颗粒）（β-AgVO _3个NRS）为流行抗生素，氯霉素（CAP）的超灵敏检测。银NP的的表面上的装饰光化学β-AgVO ₃NRs通过电磁和化学增强机制的协同作用显着增强CAP分子的拉曼信号强度。银纳米颗粒@β-AgVO的结构特征_3个-NRS青睐热点在由增强表面积的NP和自然保护区和用于与CAP分子的相互作用许多活性位点之间的界面处形成。在Ag纳米粒@β-AgVO CAP分子的SERS测量₃ -NRS节目检测（10的痕量级限制^-10 M），高均匀性（5.29％），良好的再现性（3.89％），和高的分析增强因子（2.05×10 ⁸）。所提出的SERS底物在监测自来水，牛奶和滴眼液等真实样品中具有出色的检测能力。