Modelling the dynamics of vesicle reshaping and scission under osmotic shocks,Soft Matter

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Modelling the dynamics of vesicle reshaping and scission under osmotic shocks
Soft Matter ( IF 2.9 ) Pub Date : 2021-2-16 , DOI: 10.1039/d0sm02012e
Christian Vanhille-Campos _{1,

2,

3,

4,

5} , Anđela Šarić _{1,

2,

3,

4,

5}

Affiliation

We study the effects of osmotic shocks on lipid vesicles via coarse-grained molecular dynamics simulations by explicitly considering the solute in the system. We find that depending on their nature (hypo- or hypertonic) such shocks can lead to bursting events or engulfing of external material into inner compartments, among other morphology transformations. We characterize the dynamics of these processes and observe a separation of time scales between the osmotic shock absorption and the shape relaxation. Our work consequently provides an insight into the dynamics of compartmentalization in vesicular systems as a result of osmotic shocks, which can be of interest in the context of early proto-cell development and proto-cell compartmentalisation.

中文翻译：

模拟渗透性休克下囊泡重塑和分裂的动力学

我们通过明确考虑系统中的溶质，通过粗粒分子动力学模拟研究了渗透压对脂质囊泡的影响。我们发现，根据其性质（低渗或高渗），此类冲击可导致爆裂事件或外部物质吞入内部隔室，以及其他形态变化。我们表征这些过程的动力学，并观察到渗透压吸收和形状松弛之间的时间尺度分离。因此，我们的工作提供了对由渗透性休克引起的水泡系统中隔室动态的洞察力，这在早期原始细胞发育和原始细胞隔室的背景下可能是令人感兴趣的。

更新日期：2021-02-25

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