Abstract: Narcotic drugs are often used to treat perioperative pain for patients with lung cancer. However, anesthetic management and narcotic substance use may have significant impacts on patients with lung cancer, including anti-cancer or promoting cancer effects. In this study, we summarize the effects of anesthetic management and its related substances on lung cancer. An evidence-based review of the influence of anesthetic techniques and narcotic substances used on lung cancer was performed. The effects of perioperative pain management and the method of choosing anesthesia for patients with lung cancer were explored. Different management techniques of anesthesia have been indicated to suppress both cell-mediated immunity and humoral immunity and have effects on the recurrence and metastasis of lung cancer. Evidence suggests that the effects of narcotic substances used on lung cancer were still inconsistent. However, the mechanisms by which anesthetics and analgesics inhibit the tumor are complicated. Perioperative management leads to decreased immunity in patients with lung cancer, which to some extent contributes to recurrence and metastasis. Various narcotic substances used may modulate signal pathways, including the mitochondrial pathway, and appear to exert different effects on the recurrence and metastasis of lung cancer. The anesthesiologists should consider these effects on perioperative management with lung cancer.

Keywords: narcotic substance use, anesthetics, lung cancer


中文翻译：

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当前对肺癌围手术期管理的理解：对麻醉考虑的影响

摘要：麻醉药物常用于治疗肺癌患者的围手术期疼痛。然而，麻醉管理和麻醉物质的使用可能对肺癌患者产生重大影响，包括抗癌或促癌作用。在本研究中，我们总结了麻醉管理及其相关物质对肺癌的影响。对麻醉技术和麻醉物质对肺癌的影响进行了循证审查。探讨肺癌患者围手术期疼痛管理的效果及麻醉选择方法。已表明不同的麻醉管理技术可抑制细胞介导的免疫和体液免疫，并对肺癌的复发和转移产生影响。有证据表明，使用的麻醉物质对肺癌的影响仍然不一致。然而，麻醉药和镇痛药抑制肿瘤的机制是复杂的。围手术期管理导致肺癌患者免疫力下降，这在一定程度上有助于复发和转移。使用的各种麻醉物质可能会调节信号通路，包括线粒体通路，并对肺癌的复发和转移产生不同的影响。麻醉师应考虑这些对肺癌围手术期管理的影响。围手术期管理导致肺癌患者免疫力下降，这在一定程度上有助于复发和转移。使用的各种麻醉物质可能会调节信号通路，包括线粒体通路，并对肺癌的复发和转移产生不同的影响。麻醉师应考虑这些对肺癌围手术期管理的影响。围手术期管理导致肺癌患者免疫力下降，这在一定程度上有助于复发和转移。使用的各种麻醉物质可能会调节信号通路，包括线粒体通路，并对肺癌的复发和转移产生不同的影响。麻醉师应考虑这些对肺癌围手术期管理的影响。

关键词：麻醉品使用，麻醉剂，肺癌