ABSTRACT

Objectives

Stiffness of large arteries has been related to cardiovascular mortality. Cardio-ankle vascular index (CAVI) is a novel marker of arterial stiffness. Herein, we aimed to study the relationship between fragmented QRS (fQRS) in electrocardiogram and CAVI.

Methods

Asymptomatic patients with fQRS and without fQRS were enrolled in the study consecutively. The fQRS complexes were analyzed in the 12-lead electrocardiogram. Arterial stiffness was assessed by using cardio ankle vascular index (CAVI). It was measured by a VaSera VS-1000 CAVI instrument.

Results

CAVI values of the patients with fQRS was significantly higher compared to those without fQRS (8.625 (7.9–9.2) versus 6.65 (6.7–8.4) p < .001). In a univariate analysis, it was revealed that there was a significant correlation between increased CAVI and fQRS, age, and epicardial fat thickness. Multiple binary logistic regression analysis revealed that age [95% confidence interval (CI): 1,068–1.214, p < .001] and fQRS [95% (CI): 1.766–23.117, p: 0.005] were the independent determinants of increased CAVI values.

Conclusions

ECG is a widely and readily available, inexpensive, reproducible technique that can be examined by almost every physician. fQRS values in electrocardiogram may provide a significant predictive value for arterial stiffness in asymptomatic subjects.

中文翻译：

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无症状受试者的碎片化 QRS 波群与心踝血管指数之间的关系

摘要

目标

大动脉的僵硬与心血管死亡率有关。心踝血管指数（CAVI）是一种新的动脉僵硬度指标。在此，我们旨在研究心电图中碎片 QRS (fQRS) 与 CAVI 之间的关系。

方法

有 fQRS 和没有 fQRS 的无症状患者连续纳入研究。在 12 导联心电图中分析 fQRS 复合波。通过使用心踝血管指数（CAVI）评估动脉僵硬度。它由 VaSera VS-1000 CAVI 仪器测量。

结果

fQRS 患者的 CAVI 值显着高于没有 fQRS 的患者（8.625（7.9-9.2）对 6.65（6.7-8.4）p < .001）。在单变量分析中，发现 CAVI 和 fQRS 增加、年龄和心外膜脂肪厚度之间存在显着相关性。多元二元逻辑回归分析显示，年龄 [95% 置信区间 (CI): 1,068–1.214, p < .001] 和 fQRS [95% (CI): 1.766–23.117, p: 0.005] 是 CAVI 增加的独立决定因素价值观。

结论

心电图是一种广泛且容易获得的、廉价的、可重复的技术，几乎每个医生都可以检查。心电图中的 fQRS 值可以为无症状受试者的动脉僵硬度提供重要的预测值。