ABSTRACT

This systematic review and meta-analysis of randomized controlled trials (RCTs) examined effects of mindfulness- and acceptance-based interventions (MABIs) on quality of life (QoL), coping, cognition, and mindfulness among people with multiple sclerosis (MS). Four electronic databases were searched to 3 July 2020. Data was combined in a random-effects meta-analysis model. Eighteen RCTs met the eligibility criteria. Meta-analyses at the immediate posttest found: moderate effects of MABIs on QoL, coping, and attention; and a large effect on memory. A large effect of MABIs on QoL was found at follow-up. There was no significant effect of MABIs on mindfulness. Relatively fewer studies in outcomes other than QoL were found, and the overall risk of bias across the included 18 RCTs was unclear. Future high-quality studies with follow-up evaluations are needed to support effects of MABIs on QoL, coping, cognition, and mindfulness in people with MS and examine intervention features that increase and maintain effects.

摘要

这项对随机对照试验 (RCT) 的系统评价和荟萃分析检查了正念和基于接受的干预 (MABI) 对多发性硬化症 (MS) 患者的生活质量 (QoL)、应对、认知和正念的影响。搜索了四个电子数据库，截至 2020 年 7 月 3 日。数据在随机效应荟萃分析模型中组合。18 项 RCT 符合资格标准。即时后测的荟萃分析发现：MABIs 对生活质量、应对和注意力的中等影响；并且对记忆有很大的影响。在随访中发现 MABIs 对 QoL 的影响很大。MABI 对正念没有显着影响。除了 QoL 之外，发现的结局研究相对较少，而且纳入的 18 项 RCT 的总体偏倚风险尚不清楚。