ABSTRACT

We explored the association between cognitive reserve (CR) and Parkinson' s disease (PD) related cognitive deterioration.

Forty PD patients and 12 matched healthy controls (HC) were enrolled. The PD group was balanced for the presence/absence of cognitive impairment. All participants underwent MOCA. CR was measured by the Brief Intelligence Test, and a new comprehensive tool, named Cognitive Reserve Test (CoRe-T), including sections on leisure activities and creativity.

Participants with higher CR obtained a better MOCA score irrespective of the group they belonged to. At the same time, irrespective of the CR level, the performance of the HC group was always better in comparison to the PD group. Within the PD group, a higher frequency of leisure activities was associated to be cognitively unimpaired, independently by the severity of motor symptoms and age.

CR could help to cope with PD-related cognitive decline. Its multidimensional nature could have important applications in prevention and rehabilitation interventions.

摘要

我们探讨了认知储备 (CR) 与帕金森病 (PD) 相关认知恶化之间的关联。

招募了 40 名 PD 患者和 12 名匹配的健康对照 (HC)。PD 组对认知障碍的存在/不存在进行了平衡。所有参与者都接受了 MOCA。CR 是通过简要智力测试和一个名为认知储备测试 (CoRe-T) 的新综合工具来衡量的，其中包括关于休闲活动和创造力的部分。

无论他们属于哪个组，具有较高 CR 的参与者都获得了更好的 MOCA 分数。同时，无论 CR 水平如何，HC 组的表现总是优于 PD 组。在 PD 组中，较高频率的休闲活动与认知未受损相关，独立于运动症状的严重程度和年龄。

CR 可以帮助应对 PD 相关的认知能力下降。它的多维性质可以在预防和康复干预中具有重要的应用。