Disruptions in cancer screening due to the COVID-19 pandemic may disproportionally affect patients with inherited cancer predisposition syndromes, including Lynch syndrome. Herein, we study the effect of the COVID-19 pandemic on endoscopic surveillance in Lynch syndrome through a prospective study of patients with Lynch syndrome at a tertiary referral center who were scheduled for endoscopic surveillance during the COVID-19 pandemic shutdown between March 16, 2020 and June 4, 2020. Of our cohort of 302 individuals with Lynch syndrome, 34 (11%) had endoscopic procedures scheduled during the COVID-19 pandemic shutdown. Of the 27 patients whose endoscopic surveillance was canceled during this period, 85% rescheduled procedures within 6 months with a median delay of 72 days [interquartile range (IQR), 55–84 days], with identification of an advanced adenoma or gastrointestinal cancer in 13%. Individuals who did not have a rescheduled endoscopic procedure were significantly younger than those with a rescheduled procedure [age 35 (IQR, 26–43) vs. age 55 (IQR, 43–63), P = 0.018]. Male sex was also suggestive of increasing likelihood of not having a rescheduled procedure. Taken together, our study demonstrates that the COVID-19 pandemic shutdown led to delayed endoscopic surveillance in Lynch syndrome, with potentially impactful delays among young patients. These data also emphasize the importance of timely surveillance in Lynch syndrome during this current, as well as potential future, global pandemics. Prevention Relevance: The COVID-19 pandemic has led to unprecedented disruptions in cancer screening, which may have disproportionate effects on individuals at increased cancer risk, including those with Lynch syndrome. Herein, we show that the COVID-19 pandemic led to significant disruptions in Lynch syndrome surveillance with potentially impactful delays, thus highlighting the importance of ensuring timely surveillance among this high-risk cohort.

中文翻译：

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COVID-19 对 Lynch 综合征内窥镜监测的干扰

由于 COVID-19 大流行而导致的癌症筛查中断可能会对患有遗传性癌症易感综合征（包括 Lynch 综合征）的患者产生不成比例的影响。在此，我们通过对三级转诊中心的 Lynch 综合征患者进行前瞻性研究，研究 COVID-19 大流行对 Lynch 综合征内镜监测的影响，这些患者计划在 2020 年 3 月 16 日 COVID-19 大流行停工期间进行内镜监测和 2020 年 6 月 4 日。在我们的 302 名 Lynch 综合征患者队列中，34 名（11%）在 COVID-19 大流行停工期间进行了内窥镜检查。在此期间取消内镜监测的 27 名患者中，85% 的患者在 6 个月内重新安排了手术，中位延迟为 72 天 [四分位距 (IQR)，55-84 天]，13% 的人发现了晚期腺瘤或胃肠道癌。没有重新安排内窥镜手术的人明显比重新安排手术的人年轻 [35 岁 (IQR, 26-43) 与 55 岁 (IQR, 43-63), P = 0.018]。男性也暗示不重新安排手术的可能性增加。总而言之，我们的研究表明，COVID-19 大流行的关闭导致 Lynch 综合征的内窥镜监测延迟，对年轻患者有潜在的影响。这些数据还强调了在当前以及未来潜在的全球大流行期间及时监测林奇综合征的重要性。预防相关性：COVID-19 大流行导致癌症筛查出现前所未有的中断，这可能对癌症风险增加的个体（包括林奇综合征患者）产生不成比例的影响。在此，我们表明 COVID-19 大流行导致 Lynch 综合征监测的重大中断，并可能造成影响延迟，从而强调了确保对这一高风险人群进行及时监测的重要性。