Alternative splicing (AS) is a process that produces various mRNA splicing isoforms via different splicing patterns of mRNA precursors (pre‐mRNAs). AS is the primary mechanism for increasing the types and quantities of proteins to improve biodiversity and influence multiple biological processes, including chromatin modification, signal transduction, and protein expression. It has been reported that AS is involved in the tumorigenesis and development of colorectal carcinoma (CRC). In this review, we delineate the concept, types, regulatory processes, and technical advances of AS and focus on the role of AS in CRC initiation, progression, treatment, and prognosis. This summary of the current knowledge about AS will contribute to our understanding of CRC initiation and development. This study will help in the discovery of novel biomarkers and therapeutic targets for CRC prognosis and treatment.

中文翻译：

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选择性剪接：大肠癌的重要调控机制

选择性剪接（AS）是通过mRNA前体（pre-mRNA）的不同剪接模式产生各种mRNA剪接同工型的过程。AS是增加蛋白质类型和数量以改善生物多样性并影响多种生物过程（包括染色质修饰，信号转导和蛋白质表达）的主要机制。据报道，AS参与大肠癌（CRC）的肿瘤发生和发展。在这篇综述中，我们描述了AS的概念，类型，调节过程和技术进步，并着重于AS在CRC起始，进展，治疗和预后中的作用。当前有关AS的知识的摘要将有助于我们对CRC的启动和发展的理解。