Purpose of Review

The objective of this systematic review is to present the available evidence for the utilization of the atypical opioids tapentadol, buprenorphine, and levorphanol for the treatment of neuropathic pain.

Recent Findings

In total, 1619 articles were retrieved of which 10 studies were included. Of 5 included studies pertaining to tapentadol, 4 studies show tapentadol monotherapy to be effective for the treatment of diabetic peripheral neuropathy or chronic, radiating low back pain. Of the 3 studies included for buprenorphine, only one was a randomized controlled trial found not to have a statistically significant reduction in pain with TD buprenorphine likely due to very high withdrawal rates during the trial. Only 2 case reports were included from the available literature for levorphanol providing low-quality anecdotal evidence.

Summary

The role of tapentadol, buprenorphine, and levorphanol for neuropathic pain conditions requires robust research including randomized controlled trials to evaluate their efficacy and safety.

中文翻译：

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他喷他多、丁丙诺啡和左啡诺治疗神经性疼痛：系统评价

审查目的

本系统评价的目的是提供使用非典型阿片类药物他喷他多、丁丙诺啡和左啡烷治疗神经性疼痛的可用证据。

最近的发现

总共检索到 1619 篇文章，其中包括 10 项研究。在与他喷他多有关的 5 项纳入研究中，4 项研究表明他喷他多单药治疗可有效治疗糖尿病周围神经病变或慢性、放射性腰痛。在纳入丁丙诺啡的 3 项研究中，只有一项是随机对照试验，发现使用 TD 丁丙诺啡可能由于试验期间非常高的戒断率而没有在统计学上显着减轻疼痛。现有文献中仅包含 2 例左啡诺的病例报告，提供了低质量的轶事证据。

概括

他喷他多、丁丙诺啡和左啡诺治疗神经性疼痛的作用需要强有力的研究，包括随机对照试验，以评估其疗效和安全性。