Purpose of Review

This manuscript is a systematic, narrative review that compiles and describes all data available from 2019 related to epidemiologic, diagnostic, and therapeutic advances in diabetic neuropathy (DN).

Recent Findings

Epidemiology of DN is discussed. Diagnostic modalities include predictive models, electrodiagnostics, imaging, and biomarkers. A majority of studies on the treatment of diabetic peripheral neuropathy (DPN) involve pharmacotherapy, but complementary and alternative medicine, exercise, modalities, psychological, interventional, and surgical options are also explored.

Summary

DN is a highly prevalent and debilitating consequence of diabetes that can present challenges to the clinician as the assessment is largely subjective with different phenotypic presentations among patients. Treatment of DN is largely symptomatic as the pathogenesis of DN is not fully understood and is likely multifactorial. It is evident from the broad range of treatments that too often provide unsatisfactory relief that there is no consensus about a single most effective treatment for DN, and monotherapy rarely proves to be successful.

中文翻译：

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糖尿病神经病变：对 2019 年已发布数据的批判性叙述性审查

审查目的

这份手稿是一篇系统的叙述性评论，汇编和描述了 2019 年与糖尿病神经病变 (DN) 的流行病学、诊断和治疗进展相关的所有可用数据。

最近的发现

讨论了 DN 的流行病学。诊断方式包括预测模型、电诊断、成像和生物标志物。大多数关于治疗糖尿病周围神经病变 (DPN) 的研究都涉及药物治疗，但也探索了补充和替代医学、运动、方式、心理、介入和手术选择。

概括

DN 是糖尿病的一种非常普遍且使人衰弱的后果，可能会给临床医生带来挑战，因为评估在很大程度上是主观的，患者的表型表现不同。DN 的治疗主要是对症治疗，因为 DN 的发病机制尚不完全清楚，并且可能是多因素的。从广泛的治疗方法中可以明显看出，对于 DN 的单一最有效治疗方法并没有达成共识，而且单药治疗很少证明是成功的。