Significance: Melanocytic nevi represent the most common dermal melanocytic lesions in humans. Nevus is typically diagnosed clinically with the naked eye or with dermoscopy. However, it is essential to identify the type of nevus by invasive biopsy for histopathological examination. The use of noninvasive imaging tools can be used to evaluate the types of nevi to reduce unnecessary excisions of benign entities. Aim: To evaluate the feasibility of using en face and cross-sectional full-field optical coherence tomography (FF-OCT) in differentiation of melanocytic nevi that can facilitate the reduction of unnecessary excisions of benign entities. Approach: Dual-mode Mirau-type FF-OCT for cross-sectional imaging (B-scan) and en face imaging were used to distinguish the types of nevi. Results: Although the B-scan reveals the distribution of melanosomes, users can set a specific depth of the en face image to explore the morphology of surrounding skin cells instantly. According to the locations of nevus nests, the different types of nevi, including junction nevus and compound nevus, can be identified using this dual-mode FF-OCT system. Conclusions: Combining B-scan and en face imaging in vivo FF-OCT enables the examination and navigation of skin tissues in real time and in three dimensions.

中文翻译：

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用于区分黑素细胞痣类型的体内双模全场光学相干断层扫描

意义：黑素细胞痣代表了人类最常见的皮肤黑素细胞病变。痣通常通过肉眼或皮肤镜检查进行临床诊断。然而，通过侵入性活检进行组织病理学检查来确定痣的类型是必不可少的。无创成像工具的使用可用于评估痣的类型，以减少对良性实体的不必要切除。目的：评估使用正面和横断面全场光学相干断层扫描 (FF-OCT) 区分黑素细胞痣的可行性，这有助于减少对良性实体的不必要切除。方法：使用双模式 Mirau 型 FF-OCT 进行横截面成像（B 扫描）和面部成像来区分痣的类型。结果：虽然 B 扫描揭示了黑素体的分布，用户可以设置特定深度的面部图像，立即探索周围皮肤细胞的形态。根据痣巢的位置，使用这种双模式FF-OCT系统可以识别不同类型的痣，包括交界痣和复合痣。结论：结合 B 扫描和面部成像在体 FF-OCT 能够实时和三维检查和导航皮肤组织。