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Evaluation of efficacy and safety of a polyherbal Unani formulation in diabetes mellitus type 2 (Zayābīṭus Sukkari Qism Sāni) - a randomised controlled clinical study
Indian Journal of Traditional Knowledge ( IF 0.7 ) Pub Date : 2021-02-24 N Ahmad, M Nawab, M H Kazmi, S H Fatima
Indian Journal of Traditional Knowledge ( IF 0.7 ) Pub Date : 2021-02-24 N Ahmad, M Nawab, M H Kazmi, S H Fatima
Diabetes mellitus type 2 (Zayābīṭus Sukkari Qism Sāni) is a major health concern in 21st century. Despite tremendous advances in modern sciences, there is a lack of relatively safe and effective drug for its management.
The primary objective of this study was to evaluate the efficacy and safety of a polyherbal Unani formulation containing Gurmar booti (Gymnema sylvestre), Gilo (Tinospora cordifolia) and Jamun (Syzygium cumini) in the management of Diabetes Mellitus Type 2 (DMT2). It was a randomised controlled clinical study conducted on 60 participants of DMT2 inadequately controlled by diet and exercise. The test drug was given to group-A participants (n=30) 6 g twice daily orally for 12 weeks and the standard drug metformin (500 mg) was given twice daily orally to group-B participants (n=30).
It was observed that the difference between the Mean (± SD) value of fasting blood glucose (FBG), postprandial blood glucose (PPBG) and glycosylated haemoglobin (HbA1c) in Test and Control groups at the end of the study in comparison to baseline was significant (p<0.05). This study concludes that the test drug was effective in reducing FBG and PPBG significantly in diabetic participants’ at 12 weeks of treatment.
中文翻译：
评价多草药Unani制剂在2型糖尿病（ZayābīṭusSukkari QismSāni）中的疗效和安全性-一项随机对照临床研究
2型糖尿病（ZayābīṭusSukkari QismSāni）是21世纪的主要健康问题。尽管现代科学取得了巨大进步，但仍缺乏用于管理的相对安全有效的药物。
这项研究的主要目的是评估含有Gurmar booti（Gymnema sylvestre），Gilo（Tinospora cordifolia）和Jamun（Syzygium cumini）的多草药Unani制剂的功效和安全性。) in the management of Diabetes Mellitus Type 2 (DMT2). It was a randomised controlled clinical study conducted on 60 participants of DMT2 inadequately controlled by diet and exercise. The test drug was given to group-A participants (n=30) 6 g twice daily orally for 12 weeks and the standard drug metformin (500 mg) was given twice daily orally to group-B participants (n=30).
It was observed that the difference between the Mean (± SD) value of fasting blood glucose (FBG), postprandial blood glucose (PPBG) and glycosylated haemoglobin (HbA1c) in Test and Control groups at the end of the study in comparison to baseline was significant (p<0.05). This study concludes that the test drug was effective in reducing FBG and PPBG significantly in diabetic participants’ at 12 weeks of treatment.
更新日期：2021-02-24
The primary objective of this study was to evaluate the efficacy and safety of a polyherbal Unani formulation containing Gurmar booti (Gymnema sylvestre), Gilo (Tinospora cordifolia) and Jamun (Syzygium cumini) in the management of Diabetes Mellitus Type 2 (DMT2). It was a randomised controlled clinical study conducted on 60 participants of DMT2 inadequately controlled by diet and exercise. The test drug was given to group-A participants (n=30) 6 g twice daily orally for 12 weeks and the standard drug metformin (500 mg) was given twice daily orally to group-B participants (n=30).
It was observed that the difference between the Mean (± SD) value of fasting blood glucose (FBG), postprandial blood glucose (PPBG) and glycosylated haemoglobin (HbA1c) in Test and Control groups at the end of the study in comparison to baseline was significant (p<0.05). This study concludes that the test drug was effective in reducing FBG and PPBG significantly in diabetic participants’ at 12 weeks of treatment.
中文翻译：
评价多草药Unani制剂在2型糖尿病（ZayābīṭusSukkari QismSāni）中的疗效和安全性-一项随机对照临床研究
2型糖尿病（ZayābīṭusSukkari QismSāni）是21世纪的主要健康问题。尽管现代科学取得了巨大进步，但仍缺乏用于管理的相对安全有效的药物。
这项研究的主要目的是评估含有Gurmar booti（Gymnema sylvestre），Gilo（Tinospora cordifolia）和Jamun（Syzygium cumini）的多草药Unani制剂的功效和安全性。) in the management of Diabetes Mellitus Type 2 (DMT2). It was a randomised controlled clinical study conducted on 60 participants of DMT2 inadequately controlled by diet and exercise. The test drug was given to group-A participants (n=30) 6 g twice daily orally for 12 weeks and the standard drug metformin (500 mg) was given twice daily orally to group-B participants (n=30).
It was observed that the difference between the Mean (± SD) value of fasting blood glucose (FBG), postprandial blood glucose (PPBG) and glycosylated haemoglobin (HbA1c) in Test and Control groups at the end of the study in comparison to baseline was significant (p<0.05). This study concludes that the test drug was effective in reducing FBG and PPBG significantly in diabetic participants’ at 12 weeks of treatment.
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