The study was conducted to evaluate sub-acute toxicity of cadmium (Cd) in broiler chickens and its amelioration by polyherbal mixture enriched feed (PHMEF). Thirty broiler chickens were divided into five groups. Chickens of group 1 were kept as control (C1). Chickens of group T1, T2, T3 and T4 were exposed to cadmium (as cadmium chloride) through drinking water (100 ppm), Vitamin C with Vitamin E (250 mg/kg each) in feed + Cd in drinking water (100 ppm), PHMEF (2%) alone, and PHMEF (2%) + cadmium in drinking water (100 ppm) for 28 days, respectively. Haematology, serum biochemical parameters, oxidative stress parameters like superoxide dismutase, catalase, reduced-glutathione and malondialdehyde, cadmium accumulation in organs like kidney, liver and thigh muscle, scanning electron microscopy (SEM) of ileum, and histopathological examination of kidney, liver and intestine were performed to evaluate toxicity of cadmium and ameliorating potential of PHMEF in broiler chickens. PHMEF modifies biochemical parameters, and oxidative stress markers. There was a significant reduction of cadmium accumulations in the PHMEF treated group. Polyherbal mixture enriched feed showed ameliorating effect against cadmium induced toxicity due to antioxidant effect as well as effect on accumulation of the cadmium in chickens.

中文翻译：

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镉诱导鸡的氧化应激介导的病理生理变化及其通过多草药混合饲料的改善

进行该研究以评估镉（Cd）对肉鸡的亚急性毒性以及通过多草药混合饲料（PHMEF）改善镉的效果。将三十只肉鸡分为五组。将第1组的鸡作为对照（C1）。将T1，T2，T3和T4组的鸡分别通过饮用水（100 ppm），饲料中的维生素C和维生素E（每种250 mg / kg）+饮用水中的Cd（100 ppm）暴露于镉（作为氯化镉） ，PHMEF（2％）和饮用水（100 ppm）中的PHMEF（2％）+镉分别作用28天。血液学，血清生化参数，氧化应激参数（如超氧化物歧化酶，过氧化氢酶，还原型谷胱甘肽和丙二醛），镉在肾脏，肝脏和大腿肌肉等器官中的蓄积，回肠的扫描电子显微镜（SEM），并进行了肾脏，肝脏和肠道的组织病理学检查，以评估镉的毒性和改善肉鸡PHMEF的潜力。PHMEF修改生化参数和氧化应激标记。在PHMEF治疗组中，镉积累显着减少。富含多草药混合物的饲料由于抗氧化剂作用以及对镉在鸡体内的积累的影响，对镉诱导的毒性表现出改善作用。