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Neurocognitive Outcomes and Their Diffusion Tensor Imaging Correlates in Children With Mild Traumatic Brain Injury
Journal of Child Neurology ( IF 2.0 ) Pub Date : 2021-02-24 , DOI: 10.1177/0883073821996095
Priyanka Madaan 1, 2 , Deepak Gupta 3 , Deepak Agrawal 3 , Atin Kumar 4 , Prashant Jauhari 1 , Biswaroop Chakrabarty 1 , Shobha Sharma 1 , Ravindra M Pandey 5 , Vinod K Paul 6 , Mahesh C Misra 7 , Sheffali Gulati 1
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This study aimed to assess the neurocognitive outcomes and their diffusion tensor imaging correlates in children (aged 6-16 years) with mild traumatic brain injury. This prospective analysis included 74 children with mild traumatic brain injury (52 boys; mean age: 9.5 [±2.7] years). Wechsler Intelligence Scale for Children–Indian adaptation (WISC-IV), Child Behavior Checklist, and Children’s Sleep Habits Questionnaire were administered for 57 cases (at 3 months postinjury) and 51 controls of similar age. The findings of diffusion tensor imaging (done within 7 days of injury) were correlated with various WISC-IV indices. The presenting features at the time of injury were loss of consciousness (53%), confusion or disorientation (47%), and post-traumatic amnesia (10%). Other features in the acute phase included drowsiness (86%), headache (78%), balance problems (62%), nausea (47%), fatigue (45%), vomiting (35%), nasal or ear bleed (12%), sensitivity to sound and light (12%), etc. At 3 months postinjury, the children with mild traumatic brain injury performed poorly in terms of Intelligence Quotient, perceptual reasoning index, and processing speed index as compared to controls. Based on the Child Behavior Checklist, 17% of children with mild traumatic brain injury had internalizing behavioral problems in comparison with 4% of controls. Prevalence of poor sleepers in the mild traumatic brain injury cohort and controls was 12.3% and 2% respectively. Headache, reduced attention span, and fatigue were common postconcussion symptoms. There was a positive correlation between right uncinate fasciculus fractional anisotropy and verbal comprehension index (r = 0.32; P < .05).



中文翻译:

轻度创伤性脑损伤儿童的神经认知结果及其扩散张量成像相关

本研究旨在评估轻度创伤性脑损伤儿童(6-16 岁)的神经认知结果及其弥散张量成像的相关性。这项前瞻性分析包括 74 名轻度创伤性脑损伤儿童(52 名男孩;平均年龄:9.5 [±2.7] 岁)。对 57 例(受伤后 3 个月)和 51 名年龄相近的对照组进行了韦氏儿童印度适应智力量表 (WISC-IV)、儿童行为检查表和儿童睡眠习惯问卷调查。弥散张量成像的结果(在受伤后 7 天内完成)与各种 WISC-IV 指数相关。受伤时的表现特征是意识丧失 (53%)、意识模糊或迷失方向 (47%) 和创伤后健忘症 (10%)。急性期的其他特征包括嗜睡 (86%)、头痛 (78%)、平衡问题 (62%)、恶心 (47%)、疲劳 (45%)、呕吐 (35%)、鼻或耳出血 (12%)、对声光敏感 (12%) 等。在受伤后 3 个月与对照组相比,轻度脑外伤儿童在智商、知觉推理指数和处理速度指数方面表现不佳。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(疲劳(45%)、呕吐(35%)、鼻或耳出血(12%)、对声光敏感(12%)等。在伤后3个月,轻度颅脑外伤患儿在以下方面表现不佳与对照组相比,智商、感知推理指数和处理速度指数。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(疲劳(45%)、呕吐(35%)、鼻或耳出血(12%)、对声光敏感(12%)等。在伤后3个月,轻度颅脑外伤患儿在以下方面表现不佳与对照组相比,智商、感知推理指数和处理速度指数。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(对声音和光的敏感度(12%)等。在受伤后 3 个月,与对照组相比,轻度创伤性脑损伤儿童在智商、知觉推理指数和处理速度指数方面表现不佳。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(对声音和光的敏感度(12%)等。在受伤后 3 个月,与对照组相比,轻度创伤性脑损伤儿童在智商、知觉推理指数和处理速度指数方面表现不佳。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(与对照组相比,感知推理指数和处理速度指数。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(与对照组相比,感知推理指数和处理速度指数。根据儿童行为检查表,17% 的轻度创伤性脑损伤儿童存在内化行为问题,而对照组为 4%。在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(在轻度创伤性脑损伤队列和对照组中睡眠不佳的患病率分别为 12.3% 和 2%。头痛、注意力下降和疲劳是常见的脑震荡后症状。右钩束分数各向异性与言语理解指数呈正相关(r = 0.32;P < .05)。

更新日期:2021-02-24
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