The aim of the study was to appraise the link between psoriasis and Helicobacter pylori, investigate the influence of H. pylori treatment on psoriasis severity, determine the cutoff value of haptoglobin as a psoriatic biomarker, and determine the most reliable predictor for psoriasis in patients with H. pylori. This study was carried out on 100 adult Saudi participants from the Security Forces Hospital (Riyadh, Kingdom of Saudi Arabia). All participants were allocated into 5 groups (20/group): controls (G1), psoriatic patients (G2), patients with H. pylori (G3), psoriatic patients with untreated H. pylori (G4), and psoriatic patients with treated H. pylori (G5). The study was approved by the ethics committee of Security Forces Hospital, Riyadh, Saudi Arabia. The psoriasis area and severity index (PASI) score, ¹³C-urea breath test (¹³C-UBT), C-reactive protein (CRP), haptoglobin, platelet P-selectin, cluster of differentiation 4/cluster of differentiation 8 (CD4/CD8) ratio, and lymphocyte percentages were recorded. The haptoglobin level was significantly elevated in psoriatic patients compared with G1. In G5, there was significant attenuation in the PASI score, P-selectin, CRP, CD4/CD8 ratio, and lymphocyte percentage compared with G4. There was a significant positive correlation between psoriasis severity and ¹³C-UBT. In addition, ¹³C-UBT and PASI scores were significantly positively correlated with CRP, platelet P-selectin, and percentage of lymphocytes. H. pylori plays a potential role in psoriasis pathogenesis. H. pylori treatment attenuates psoriasis severity. Haptoglobin could be utilized as a psoriatic biomarker with 1.95 g/L as the cutoff value. The most reliable predictor for psoriasis in infected patients with H. pylori is ¹³C-UBT.

中文翻译：

---

幽门螺杆菌感染对银屑病严重程度的临床意义

该研究的目的是评估银屑病与幽门螺杆菌之间的联系，研究幽门螺杆菌治疗对银屑病严重程度的影响，确定结合珠蛋白作为银屑病生物标志物的临界值，并确定银屑病患者银屑病最可靠的预测指标。幽门螺杆菌。这项研究是对来自安全部队医院（沙特阿拉伯王国利雅得）的 100 名成年沙特参与者进行的。所有的受试者都分为5组（20 /组）：对照组（G1），银屑病患者（G2），患者的幽门螺旋杆菌（G3），银屑病患者与未处理的幽门螺杆菌（G4），和牛皮癣患者的治疗ħ . 幽门螺杆菌(G5)。该研究得到了沙特阿拉伯利雅得安全部队医院伦理委员会的批准。银屑病面积和严重程度指数 (PASI) 评分、¹³ C-尿素呼气试验 ( ¹³ C-UBT)、C-反应蛋白 (CRP)、结合珠蛋白、血小板 P-选择素、分化簇 4/分化簇 8 (CD4 /CD8) 比率，并记录淋巴细胞百分比。与 G1 相比，银屑病患者的触珠蛋白水平显着升高。在 G5 中，与 G4 相比，PASI 评分、P-选择素、CRP、CD4/CD8 比率和淋巴细胞百分比显着减弱。银屑病严重程度与¹³ C-UBT呈显着正相关。此外，¹³C-UBT 和 PASI 评分与 CRP、血小板 P-选择素和淋巴细胞百分比显着正相关。H. pylori在银屑病发病机制中发挥潜在作用。H. pylori治疗可减轻银屑病的严重程度。触珠蛋白可用作银屑病生物标志物，临界值为 1.95 g/L。幽门螺杆菌感染患者银屑病最可靠的预测指标是¹³ C-UBT。