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Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
Human Reproduction Update ( IF 14.8 ) Pub Date : 2020-12-06 , DOI: 10.1093/humupd/dmaa049
Natasha Pritchard 1, 2 , Tu'uhevaha Kaitu'u-Lino 1, 2, 3 , Lynda Harris 4, 5, 6 , Stephen Tong 1, 2 , Natalie Hannan 1, 2, 7
Affiliation  

Nanotechnology involves the engineering of structures on a molecular level. Nanomedicine and nano-delivery systems have been designed to deliver therapeutic agents to a target site or organ in a controlled manner, maximizing efficacy while minimizing off-target effects of the therapeutic agent administered. In both reproductive medicine and obstetrics, developing innovative therapeutics is often tempered by fears of damage to the gamete, embryo or developing foetus or of negatively impacting a woman’s reproductive potential. Thus, nanomedicine delivery systems may provide alternative targeted intervention strategies, treating the source of the disease and minimizing long-term consequences for the mother and/or her foetus.

中文翻译:


怀孕中的纳米颗粒:生殖治疗的下一个前沿



纳米技术涉及分子水平上的结构工程。纳米医学和纳米递送系统被设计为以受控方式将治疗剂递送至目标部位或器官,最大化疗效,同时最小化所施用治疗剂的脱靶效应。在生殖医学和产科领域,创新疗法的开发往往因担心配子、胚胎或发育中的胎儿受损或对女性生殖潜力产生负面影响而受到影响。因此,纳米药物输送系统可以提供替代的有针对性的干预策略,治疗疾病的根源并最大限度地减少对母亲和/或其胎儿的长期后果。
更新日期:2020-12-06
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