UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory process after allogeneic hematopoietic stem cell transplantation (SCT), so UNC93B1 might play integral roles there. We investigated the influence of the UNC93B1 single-nucleotide polymorphism (SNP) rs308328 (T>C) on transplant outcomes in a cohort of 237 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. The donor UNC93B1 C/C genotype was associated with a better 3-year overall survival than the donor UNC93B1 C/T or T/T genotype. An analysis of the UNC93B1 rs308328 genotype may therefore be useful for selecting the donor, estimating the prognosis, and creating therapeutic strategies after allogeneic SCT.

UNC-93 同系物 B1 (UNC93B1) 是 Toll 样受体 (TLR) 的关键调节因子，TLR 是一种模式识别受体，可感知入侵的病原体并管理先天免疫反应，并将它们从内质网递送至各自的内体信号室。已知有几种类型的 TLR 在同种异体造血干细胞移植 (SCT) 后促进炎症过程，因此 UNC93B1 可能在那里发挥不可或缺的作用。我们调查了UNC93B1单核苷酸多态性 (SNP) rs308328 (T>C) 对 237 名通过日本骨髓捐赠计划接受无关 HLA 匹配骨髓移植 (BMT) 治疗恶性血液病患者的移植结果的影响。供体UNC93B1与供体UNC93B1 C/T 或 T/T 基因型相比，C/C 基因型与更好的 3 年总体生存率相关。因此，对UNC93B1 rs308328 基因型的分析可能有助于选择供体、估计预后以及制定同种异体 SCT 后的治疗策略。