Abstract

The synthesis of quinoline (C₉H₇N) and its derivatives attracted the attention of various research communities due to their prominent roles in medicinal chemistry, coordination chemistry and material chemistry. Because of the requirement for accessing them on an industrial scale, large numbers of chemist efforts are devoted to developing various synthetic methods to obtain these versatile heterocycles in a cost-effective and environmentally supportive manner. This review will summarize the different conventional methods of synthesis of quinolines, and also entrenching special technique approaches such as Microwave-Assisted Organic Synthesis (MAOS), multicomponent reactions, solvent-free reaction conditions, ionic liquids (IL’s), ultrasound-promoted synthesis, phase-transfer catalyst (PTC), photo-catalyst, heterogeneous, homogeneous, and biocatalysis.

摘要

喹啉的合成（C ₉ H ₇N）及其衍生物因其在药物化学，配位化学和材料化学中的突出作用而引起了各个研究界的关注。由于需要以工业规模获得它们，因此大量化学家的努力致力于开发各种合成方法，从而以具有成本效益和对环境有益的方式获得这些通用的杂环。这篇综述将概述喹啉的不同常规合成方法，并巩固特殊技术方法，例如微波辅助有机合成（MAOS），多组分反应，无溶剂反应条件，离子液体（IL's），超声促进合成，相转移催化剂（PTC），光催化剂，非均相，均相和生物催化。