ABSTRACT

Background

The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress could be an unavoidable effect derived even from the surgical procedure itself.

Methods

A systematic review was performed following an electronic search of Pubmed and ScienceDirect databases. Keywords such as sepsis, oxidative stress, organ dysfunction, antioxidants, outcomes in postoperative complications, among others, were used. Review articles were preferably used between the years 2015 onwards, not excluding older ones.

Results

The vast majority point to the role of oxidative stress in generating greater damage and worse prognosis in postoperative patients without the necessary care and precautions, taking importance on the use of antioxidants to prevent this problem.

Discussions

Oxidative stress represents a common final pathway related to pathological processes such as inflammation or ischemia–reperfusion, among others. The expression of greater severity of these complications can result in multiple organ dysfunction or sepsis. The aim of this study was to present an update of the role of oxidative stress on surgical postoperative complications.

中文翻译：

---

氧化应激在术后并发症和多器官功能障碍综合征机制中的作用

摘要

背景

手术后的损伤程度多年来一直是研究的主题。许多手术并发症会影响患者的术后生活质量，甚至会导致死亡。尽管这些并发症通常是由多因素机制引起的，但氧化应激起着关键的病理生理作用。此外，即使是外科手术本身，氧化应激也可能是一种不可避免的影响。

方法

在对 Pubmed 和 ScienceDirect 数据库进行电子搜索后进行了系统评价。使用了脓毒症、氧化应激、器官功能障碍、抗氧化剂、术后并发症结果等关键词。评论文章最好在 2015 年以后使用，不排除较旧的文章。

结果

绝大多数人指出，在没有必要的护理和预防措施的情况下，氧化应激会在术后患者中产生更大的损伤和更差的预后，因此重视使用抗氧化剂来预防这一问题。

讨论

氧化应激代表了与炎症或缺血再灌注等病理过程相关的共同最终途径。这些并发症更严重的表现可导致多器官功能障碍或败血症。本研究的目的是更新氧化应激对手术术后并发症的作用。