The family Enterobacteriaceae has undergone significant morphogenetic changes in its more than 85-year history, particularly during the past 2 decades (2000 to 2020). The development and introduction of new and novel molecular methods coupled with innovative laboratory techniques have led to many advances. We now know that the global range of enterobacteria is much more expansive than previously recognized, as they play important roles in the environment in vegetative processes and through widespread environmental distribution through insect vectors. In humans, many new species have been described, some associated with specific disease processes. Some established species are now observed in new infectious disease settings and syndromes. The results of molecular taxonomic and phylogenetics studies suggest that the current family Enterobacteriaceae should possibly be divided into seven or more separate families. The logarithmic explosion in the number of enterobacterial species described brings into question the relevancy, need, and mechanisms to potentially identify these taxa. This review covers the progression, transformation, and morphogenesis of the family from the seminal Centers for Disease Control and Prevention publication (J. J. Farmer III, B. R. Davis, F. W. Hickman-Brenner, A. McWhorter, et al., J Clin Microbiol 21:46–76, 1985, https://doi.org/10.1128/JCM.21.1.46-76.1985) to the present.

中文翻译：

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肠杆菌科 (Order: "Enterobacterales") 的变化：新成员、分类学问题、地理扩张以及新疾病和疾病综合征

肠杆菌科在其超过 85 年的历史中，尤其是在过去 20 年（2000 年至 2020 年）期间，经历了显着的形态发生变化。新的和新颖的分子方法的开发和引入与创新的实验室技术相结合，带来了许多进步。我们现在知道，全球肠杆菌的范围比以前认识的要广泛得多，因为它们在营养过程中的环境中以及通过昆虫媒介广泛的环境分布中发挥着重要作用。在人类中，已经描述了许多新物种，其中一些与特定的疾病过程有关。现在在新的传染病环境和综合征中观察到一些已建立的物种。分子分类学和系统发育学研究结果表明，目前的肠杆菌科应该可能分成七个或更多独立的家庭。所描述的肠杆菌种类数量的对数爆炸带来了对潜在识别这些分类群的相关性、需求和机制的质疑。这篇综述涵盖了疾病控制和预防中心的开创性出版物 (JJ Farmer III, BR Davis, FW Hickman-Brenner, A. McWhorter, et al., J Clin Microbiol 21:46) 中家庭的进展、转化和形态发生–76, 1985, https://doi.org/10.1128/JCM.21.1.46-76.1985) 至今。