This study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma. Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal downregulation of the fatty acid metabolism pathway occurred in all three renal cell carcinoma subtypes. Alteration of the fatty acid metabolism pathway was vital in the development of pan-renal cell carcinoma. Bioinformatics methods were used to obtain a panoramic view of copy number variation, single-nucleotide variation, mRNA expression, and the survival landscape of fatty acid metabolism pathway-related genes in pan-renal cell carcinoma. Most importantly, we used genes related to the fatty acid metabolism pathway to establish a prognostic-related risk model in the three subtypes of renal cell carcinoma. The data will be valuable for future clinical treatment and scientific research.

中文翻译：

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泛肾细胞癌中脂肪酸代谢途径的比较：来自生物信息学的证据

本研究分析和比较了脂肪酸代谢途径在肾细胞癌三种亚型中的潜在作用。通过亚型中的基因组变异分析确定了异常上调和下调的生物途径。所有三种肾细胞癌亚型都发生了脂肪酸代谢途径的异常下调。脂肪酸代谢途径的改变在泛肾细胞癌的发展中至关重要。使用生物信息学方法获得了泛肾细胞癌中脂肪酸代谢途径相关基因的拷贝数变异、单核苷酸变异、mRNA表达和存活情况的全景图。最重要的是，我们使用与脂肪酸代谢途径相关的基因在肾细胞癌的三个亚型中建立了预后相关的风险模型。这些数据对未来的临床治疗和科学研究具有重要价值。