A three-dimensional optical coherence tomography (OCT) crystalline lens imaging method based on oblique scanning and image stitching is presented. The method was designed to increase OCT imaging volume of crystalline lens in vivo. A long-range swept-source (SS)-OCT imaging system, which can measure the entire anterior segment of eye in a single acquisition, is used to acquire one central volume and 4 extra volumes with different angles between optical axis of OCT instrument and the pupillary axis. The volumes are then stitched automatically by developed software. To show its effectiveness and verify its validity, we scanned the subjects before and after pupil dilation drops and compared the experimental results. By determining the number of voxels representing the signal from the crystalline lens in 3-D OCT images, our method can provide around 17% additional volumetric lens coverage compared with a regular imaging procedure. The proposed approach could be used clinically in early diagnosis of cortical cataract. Wider field of view offered by this method may facilitate more accurate lens biometry in its peripheral zones, which potentially contributes to understanding of lens shape modifications of the accommodating eye.

中文翻译：

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在光学相干断层扫描中通过斜扫描和体积缝合增加了晶状体的覆盖范围

提出了一种基于倾斜扫描和图像拼接的三维光学相干断层扫描（OCT）晶状体成像方法。该方法旨在增加体内晶状体的OCT成像量。一种远程扫描源（SS）-OCT成像系统，可在一次采集中测量整个眼前段，用于采集一个中心体积和4个额外的体积，OCT仪器的光轴与OCT仪器的光轴之间的角度不同瞳孔轴。然后通过开发的软件自动缝合这些卷。为了显示其有效性并验证其有效性，我们扫描了瞳孔散瞳滴落前后的受试者，并比较了实验结果。通过确定表示3D OCT图像中来自晶状体的信号的体素数量，与常规成像过程相比，我们的方法可提供约17％的额外体积晶状体覆盖率。所提出的方法可在临床上用于皮质性白内障的早期诊断。