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Digital adaptive optics based on digital lateral shearing of the computed pupil field for point scanning retinal swept source OCT
Biomedical Optics Express ( IF 2.9 ) Pub Date : 2021-02-23 , DOI: 10.1364/boe.416569
Abhishek Kumar 1, 2 , Stefan Georgiev 1, 3 , Matthias Salas 1 , Rainer A. Leitgeb 1
Affiliation  

A novel non-iterative digital adaptive optics technique is presented in which the wavefront error is calculated using the phase difference between the pupil field and its digital copies translated by a pixel along the horizontal and vertical direction in the pupil plane. This method provides slope data per pixel, thus can generate > 50k local slope data samples for a circular pupil of diameter 256 pixels with high accuracy and dynamic range. It offers more than 12x faster computational speed in comparison to the sub-aperture based digital adaptive optics method. Furthermore, it is independent of any system parameters, the light distribution in the pupil plane, or the intensity of the image. The technique is useful in applications such as interferometric or digital holography based microscopy, metrology, and as digital wavefront sensor in adaptive optics, where focusing of light in the sample is involved that creates a guide star or where the sample itself exhibits guide star-like structures. This technique is implemented in a point scanning swept-source OCT at 1060 nm, and a large wavefront error with a peak to valley of 20 radians and root mean square error of 0.71 waves is detected and corrected in case of a micro-beads phantom sample. Also, human photoreceptor images are recovered from aberrated retinal OCT volumes acquired at eccentricities of 2 and 2.5 degrees from the fovea in vivo.

中文翻译:

基于数字横向剪切的计算出的瞳孔的数字自适应光学器件,用于点扫描视网膜扫掠源OCT

提出了一种新颖的非迭代式数字自适应光学技术,其中,利用光瞳场及其在像素中沿水平和垂直方向在水平方向和垂直方向平移的数字副本之间的相位差来计算波前误差。该方法提供每个像素的斜率数据,因此可以为直径为256像素的圆形光瞳生成高精度的动态范围> 50k的局部斜率数据样本。与基于子孔径的数字自适应光学方法相比,它提供了12倍以上的计算速度。此外,它与任何系统参数,光瞳平面中的光分布或图像强度无关。该技术在基于干涉或数字全息的显微镜,计量学,作为自适应光学系统中的数字波前传感器,其中涉及样品中光的聚焦以产生引导星,或者样品本身表现出类似于引导星的结构。此技术在1060 nm的点扫描扫频源OCT中实施,在微珠体模样本的情况下,检测到并校正了波前误差较大的波前误差,峰到谷的弧度为20弧度,且均方根误差为0.71波。此外,还可以从以中央凹为中心的2和2.5度的偏心度获取的畸形视网膜OCT体积中恢复人体感光图像。对于微珠体模样品,检测到并校正了波前误差,波峰误差的峰谷至最大值为20弧度,均方根误差为0.71。此外,还可以从以中央凹为中心的2和2.5度的偏心度获取的畸形视网膜OCT体积中恢复人体感光图像。对于微珠体模样品,检测到并校正了波前误差,波峰误差的峰谷至最大值为20弧度,均方根误差为0.71。此外,还可以从以中央凹为中心的2和2.5度的偏心度获取的畸形视网膜OCT体积中恢复人体感光图像。体内
更新日期:2021-03-01
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