Ni-Catalyzed Intermolecular C(sp3)–H Amidation Tuned by Bidentate Directing Groups,ACS Catalysis

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Ni-Catalyzed Intermolecular C(sp3)–H Amidation Tuned by Bidentate Directing Groups
ACS Catalysis ( IF 11.3 ) Pub Date : 2021-02-23 , DOI: 10.1021/acscatal.1c00070
Yeong Bum Kim _{1,

2} , Joonghee Won _{1,

2} , Jeonghyo Lee _{1,

2} , Junho Kim _{1,

2} , Bingwei Zhou _{1,

2} , Jung-Woo Park _{1,

2} , Mu-Hyun Baik _{1,

2} , Sukbok Chang _{1,

2}

Affiliation

We disclose herein a directing group-assisted nickel-catalyzed intermolecular C(sp³)–H amidation using organic azides as nitrene precursors. With the installation of an electronically tailored directing group, enhanced amidation efficiency was achieved. A series of experimental and computational studies suggested that a putative nickel(III)-nitrenoid species is a key intermediate in the C–N bond-forming process.

中文翻译：

镍催化双分子定向基团修饰的分子间C（sp ³）–H酰胺化反应

我们在本文中公开了使用有机叠氮化物作为腈前体的定向基团辅助镍催化的分子间C（sp ³）-H酰胺化反应。通过安装电子定制的指导小组，可以提高酰胺化效率。一系列的实验和计算研究表明，假定的镍（III）-类胡萝卜素物质是C–N键形成过程中的关键中间体。

更新日期：2021-03-05

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