ABSTRACT

Background: Pharmacological-assisted psychotherapies, using conventional and novel drug agents, are increasingly being used both in clinical and experimental research settings, respectively.

Objective: To determine the efficacy of conventional and novel pharmacological-assisted psychotherapies in reducing PTSD symptom severity.

Method: A systematic review and meta-analysis of randomised-controlled trials were undertaken; 21 studies were included.

Results: MDMA-assisted therapy was found to statistically superior to active and inactive placebo-assisted therapy in reduction of PTSD symptoms (standardised mean difference −1.09, 95% CI −1.60 to −0.58). There was no evidence of superiority over placebo for any other intervention.

Conclusions: MDMA-assisted therapy demonstrated an impressive effect size; however, it is difficult to have confidence at this stage in this intervention due to the small numbers of participants included, and more research in this area is needed. There was no evidence to support the efficacy of any other drug-assisted interventions.

摘要

背景：使用传统药物和新型药物的药物辅助心理治疗分别越来越多地用于临床和实验研究环境。

目的：确定常规和新型药物辅助心理疗法在减轻 PTSD 症状严重程度方面的功效。

方法：对随机对照试验进行了系统评价和荟萃分析；纳入了 21 项研究。

结果：发现 MDMA 辅助疗法在减少 PTSD 症状方面在统计学上优于活性和非活性安慰剂辅助疗法（标准化平均差 -1.09，95% CI -1.60 至 -0.58）。没有证据表明任何其他干预措施优于安慰剂。

结论：MDMA 辅助治疗显示出令人印象深刻的效果；然而，由于参与者人数较少，现阶段很难对该干预措施有信心，需要在这方面进行更多研究。没有证据支持任何其他药物辅助干预的有效性。