Abstract

Orthopedic device related infections (ODRI’s) represent a difficult to treat situation owing to their biofilm based nature. Biofilm infections once established are difficult to eradicate even with an aggressive treatment regimen due to their recalcitrance towards antibiotics and immune attack. The involvement of antibiotic resistant pathogens as the etiological agent further worsens the overall clinical picture, pressing on the need to look into alternative treatment strategies. The present review highlightes the microbiological challenges associated with treatment of ODRI’s due to biofilm formation on the implant surface. Further, it details the newer anti-infective modalities that work either by preventing biofilm formation and/or through effective disruption of the mature biofilms formed on the medical implant. The study, therefore aims to provide a comprehensive insight into the newer anti-biofilm interventions (non-antibiotic approaches) and a better understanding of their mechanism of action essential for improved management of orthopedic implant infections.

摘要

骨科设备相关的感染（OD​​RI's）由于其基于生物膜的性质而难以治疗。一旦确定了生物膜感染，即使采用积极的治疗方案也很难根除，因为它们对抗生素和免疫攻击不服。抗生素抗性病原体作为病原体的参与进一步恶化了整体临床状况，迫切需要寻找替代治疗策略。本综述重点介绍了由于种植体表面生物膜形成而与ODRI治疗相关的微生物学挑战。此外，它详述了通过防止生物膜形成和/或通过有效破坏在医疗植入物上形成的成熟生物膜而起作用的新型抗感染方式。研究，