Rickettsia felis, a Gram‐negative bacterium that causes spotted fever, is of increasing interest as an emerging human pathogen. R. felis and several other Rickettsia strains are classed as National Institute of Allergy and Infectious Diseases priority pathogens. In recent years, R. felis has been shown to be adaptable to a wide range of hosts, and many fevers of unknown origin are now being attributed to this infectious agent. Here, the structure of acetoacetyl‐CoA reductase from R. felis is reported at a resolution of 2.0 Å. While R. felis acetoacetyl‐CoA reductase shares less than 50% sequence identity with its closest homologs, it adopts a fold common to other short‐chain dehydrogenase/reductase (SDR) family members, such as the fatty‐acid synthesis II enzyme FabG from the prominent pathogens Staphylococcus aureus and Bacillus anthracis. Continued characterization of the Rickettsia proteome may prove to be an effective means of finding new avenues of treatment through comparative structural studies.

中文翻译：

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猫立克次体乙酰乙酰辅酶A还原酶的晶体结构

猫立克次体是一种引起斑疹热的革兰氏阴性细菌，作为一种新兴的人类病原体越来越受到人们的关注。猫立克次体和其他几种立克次体菌株被列为国家过敏和传染病研究所的优先病原体。近年来，猫红线虫已被证明能够适应多种宿主，许多不明原因的发烧现在都归因于这种传染原。此处，以 2.0 Å 的分辨率报道了来自猫科动物的乙酰乙酰辅酶 A 还原酶的结构。虽然猫乙酰乙酰辅酶 A 还原酶与其最接近的同源物具有不到 50% 的序列同一性，但它采用了其他短链脱氢酶/还原酶 (SDR) 家族成员所共有的折叠，例如脂肪酸合成 II 酶 FabG突出的致病菌为金黄色葡萄球菌和炭疽杆菌。立克次体蛋白质组的持续表征可能被证明是通过比较结构研究寻找新治疗途径的有效手段。