Functional analysis of ABCG and ABCH transporters from the red flour beetle, Tribolium castaneum,Pest Management Science

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Functional analysis of ABCG and ABCH transporters from the red flour beetle, Tribolium castaneum
Pest Management Science ( IF 3.8 ) Pub Date : 2021-02-23 , DOI: 10.1002/ps.6332
Janin Rösner ₁ , Johanne Tietmeyer ₂ , Hans Merzendorfer ₁

Affiliation

ATP‐binding cassette transporter (ABC transporter) subfamilies ABCA–C and ABCG–H have been implicated in insecticide detoxification, mostly based on findings of elevated gene expression in response to insecticide treatment. We previously characterized TcABCA–C genes from the model beetle and pest Tribolium castaneum and demonstrated that TcABCA and TcABCC genes are involved in the elimination of diflubenzuron, because RNA interference (RNAi)‐mediated gene silencing increased susceptibility. In this study, we focused on the potential functions of TcABCG and TcABCH genes in insecticide detoxification.

中文翻译：

红面粉甲虫Tribolium castaneum的ABCG和ABCH转运蛋白的功能分析

ATP结合盒转运蛋白（ABC转运蛋白）亚家族ABCA–C和ABCG–H与杀虫剂解毒有关，主要是基于对杀虫剂处理产生的基因表达升高的发现。我们先前从模型甲虫和害虫Tribolium castaneum中鉴定了TcABCA–C基因，并证明TcABCA和TcABCC基因参与了双氟苯隆的消除，因为RNA干扰（RNAi）介导的基因沉默增加了敏感性。在这项研究中，我们集中于TcABCG和TcABCH基因在杀虫剂解毒中的潜在功能。

更新日期：2021-02-23

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