Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an urgent need for the development of novel medications. The endocannabinoid system modulates pain perception and drugs targeting the cannabinoid receptor type 2 (CB2) devoid of psychoactive side effects could emerge as novel analgesics. An interesting model to evaluate the mechanisms underlying resistance to pain is the fragile X mental retardation protein knockout mouse (Fmr1KO), a model of fragile X syndrome that exhibits nociceptive deficits and fails to develop neuropathic pain.

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内源性大麻素系统在患有神经性疼痛的脆性 X 小鼠模型中的作用

神经性疼痛是一种复杂的疾病，其特征是感觉、认知和情感症状，这些症状会放大疼痛的感知。潜在的致病机制在很大程度上是未知的，迫切需要开发新的药物。内源性大麻素系统调节痛觉，靶向大麻素受体 2 (CB2) 且没有精神副作用的药物可能会成为新型镇痛药。评估抵抗疼痛的潜在机制的一个有趣模型是脆性 X 智力低下蛋白敲除小鼠 (Fmr1KO)，这是一种表现出伤害性缺陷且无法发展为神经性疼痛的脆性 X 综合征模型。