Aging is a biological process caused by the accumulation of senescent cells with a permanent proliferative arrest. To the influence of aging on human life expectancy, there is essential for new biomarkers which possibly will assistance in recognizing age-associated pathologies. Exosomes, which are cell-secreted nanovesicles, make available a new biomarker detection and therapeutic approach for the transfer of different molecules with high capacity. Recently, non-coding RNAs (ncRNA) which are contained in exosomes have developed as important molecules regulating the complexity of aging and relevant human diseases. The discovery of ncRNA provided perceptions into an innovative regulatory platform that could interfere with cellular senescence. The non-coding transcriptome includes a different of RNA species, spanning from short ncRNAs (<200 nucleotides) to long ncRNAs, that are >200 bp long. Upgraded evidence displays that targeting ncRNAs possibly will influence senescence pathways. In this article, we will address ncRNAs that participated in age-related and cellular senescence diseases. Growing conception of ncRNAs in the aging process possibly will be responsible for new understandings into the improvement of age-related diseases and elongated life span.

中文翻译：

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外泌体非编码RNA在衰老相关疾病中的作用

衰老是一种生物过程，由具有永久性增殖停滞的衰老细胞的积累引起。对于衰老对人类预期寿命的影响，需要新的生物标志物，这可能有助于识别与年龄相关的病理。外泌体是细胞分泌的纳米囊泡，为高容量不同分子的转移提供了一种新的生物标志物检测和治疗方法。最近，包含在外泌体中的非编码 RNA (ncRNA) 已发展成为调节衰老和相关人类疾病复杂性的重要分子。ncRNA 的发现提供了对可能干扰细胞衰老的创新监管平台的看法。非编码转录组包括不同的 RNA 种类，从短的 ncRNA（< 200 个核苷酸）到长 ncRNA，即 >200 bp 长。升级的证据表明，靶向 ncRNA 可能会影响衰老途径。在本文中，我们将讨论参与年龄相关和细胞衰老疾病的 ncRNA。ncRNA 在衰老过程中不断增长的概念可能有助于对改善与年龄相关的疾病和延长寿命产生新的认识。