Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells, it was thought that the formation of stress granules could protect them from apoptosis and induces resistance towards anti-cancer drugs or radiation treatment which makes the stress granules a potential target for cancer treatment. However, most of our understanding of stress granules are still in the stage of molecular and cell biology, and a transitional gap for its actual effect on clinical settings remains. In this review, we summarize the mechanism and effect of stress granules formation in cancer and try to illuminate its potential applications in cancer therapy, using breast cancer as an example.

应激颗粒是由各种应激条件诱导的非膜性细胞质病灶。这是细胞在压力期间抑制整体翻译的一种保护策略。在癌细胞中，人们认为应激颗粒的形成可以保护它们免于凋亡并诱导对抗癌药物或放射治疗的抗性，这使得应激颗粒成为癌症治疗的潜在目标。然而，我们对应激颗粒的大部分理解仍处于分子和细胞生物学阶段，其对临床环境的实际影响仍存在过渡性差距。在这篇综述中，我们以乳腺癌为例，总结了应激颗粒在癌症中形成的机制和作用，并试图阐明其在癌症治疗中的潜在应用。