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Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness
Trends in Immunology ( IF 13.1 ) Pub Date : 2021-02-23 , DOI: 10.1016/j.it.2021.02.007 Sandra Demaria , Silvia C. Formenti
中文翻译:
肝转移照射可恢复免疫治疗的反应性
更新日期:2021-03-25
Trends in Immunology ( IF 13.1 ) Pub Date : 2021-02-23 , DOI: 10.1016/j.it.2021.02.007 Sandra Demaria , Silvia C. Formenti
Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.
中文翻译:
肝转移照射可恢复免疫治疗的反应性
同种异体肝移植耐受免疫系统,防止同一供体的器官排斥。Yu等人的最新文章。研究表明,肝转移同样可以预防免疫治疗的鼠和人宿主的肿瘤排斥。此外,放射线可以重编程肝脏微环境,以恢复全身性肿瘤排斥反应。