Urinary tract infections (UTI) represent one of the most common problem within the urological disorders, and it is mainly caused by biofilm formation which leads to bacterial infection. Anti-adhesion and antibacterial agents are two primary mechanisms to prevent biofilm formation; however, current strategies are insufficiently effective. In this study, we developed an effective antibiofilm biodegradable polymer with high biocompatibility. Here we embedded silver nanoparticles (AgNPs) in poly(glycerol sebacate) acrylate (PGSA) followed by superhydrophilic modification on the polymer surfaces. The modified surfaces were characterized using SEM, AFM and contact angle measurements. This anti-adhesive surface prevented the adhesion of E. coli and limited the biofilm coverage percentage to less than 3% in 24 h. In the in vitro degradation, the long-term antibiofilm performance was evaluated in Nowatzki-Stoodley artificial urine (NSAU). The surface modified AgNPs embedded PGSA (sPGSA-AgNPs) was able to effectively inhibit the formation of biofilm by reducing the biofilm coverage to less than 0.01%, and it also showed low cytotoxicity with human bladder carcinoma cell. With the effective antibiofilm, biocompatibility and biodegradability, it is possible to be applied in urological devices to ameliorate the situation of UTIs.

泌尿道感染（UTI）是泌尿外科疾病中最常见的问题之一，主要由生物膜形成引起，导致细菌感染。抗粘连和抗菌剂是防止生物膜形成的两个主要机制。但是，当前的策略效果不佳。在这项研究中，我们开发了一种具有高生物相容性的有效抗生物膜生物可降解聚合物。在这里，我们将银纳米颗粒（AgNPs）嵌入聚癸二酸甘油酯（PGSA）中，然后在聚合物表面进行超亲水改性。使用SEM，AFM和接触角测量对改性后的表面进行表征。这种抗粘性的表面阻止了大肠杆菌的粘附并在24小时内将生物膜覆盖率限制在3％以下。在体外降解中，在Nowatzki-Stoodley人工尿液（NSAU）中评估了长期的抗生物膜性能。表面修饰的AgNPs嵌入的PGSA（sPGSA-AgNPs）能够通过将生物膜覆盖率降低至小于0.01％来有效抑制生物膜的形成，并且对人膀胱癌细胞的细胞毒性也很低。凭借有效的抗生物膜，生物相容性和生物降解性，可以在泌尿科设备中应用，以改善泌尿道感染的状况。