The palladium-catalyzed selective activation of CH bonds is of great importance for the construction of diverse bioactive molecules. Herein, monodisperse CuPd alloy nanoparticles supported on reduced graphene oxide have been used as high efficient and recyclable catalyst for C(sp³)−H acyloxylation of 8-methylquinolines in good yields under mild conditions. The developed catalytic system proceeds with low palladium loading, good catalyst recyclability, high step and atom efficiency, excellent chemo and regioselectivity, good substrate and functional group compatibility, and applicable for large scale up synthesis. Preliminary studies were carried out to gain insights into the heterogeneous catalysis mechanism.

钯催化的C H键的选择性活化对于构建各种生物活性分子非常重要。在本文中，负载在还原的氧化石墨烯上的单分散CuPd合金纳米颗粒已被用作高效且可回收的催化剂，用于在温和的条件下以良好的收率实现8-甲基喹啉的C（sp ³）-H酰氧基化。所开发的催化系统具有低钯载量，良好的催化剂可回收性，较高的步长和原子效率，优异的化学和区域选择性，良好的底物和官能团相容性，并适用于大规模上规模合成。进行了初步研究，以了解多相催化机理。