Gastric cancer (GC) is a significant global health problem, with Helicobacter pylori infection estimated to be responsible for 89% of non-cardiac GC cases, or 78% of all GC cases. The International Agency for Research on Cancer has called for Helicobacter pylori test-and-treat strategies in countries with high rates of GC. However, for countries with low rates of GC, such as most Western countries, the balance between benefits, harms and costs of screening is less clear-cut. GC is a disease with a well-characterized precancerous process, providing the basis for primary and secondary prevention efforts. However, rigorous data assessing the impact of such interventions in Western countries are lacking. In the absence of clinical trials, modelling offers a unique approach to evaluate the potential impact of various screening and surveillance interventions. In this paper, we provide an overview of modelling studies evaluating the cost-effectiveness of GC screening and surveillance in Western countries.

胃癌（GC）是一个严重的全球性健康问题，幽门螺杆菌感染估计占非心脏GC病例的89％，占所有GC病例的78％。国际癌症研究机构已呼吁在GC率高的国家实施幽门螺杆菌检测和治疗策略。但是，对于GC率较低的国家（例如大多数西方国家），筛查的收益，危害和成本之间的平衡不太明确。胃癌是一种具有特征明确的癌前过程的疾病，为原发性肝癌和肝癌提供了基础。二级预防工作。但是，缺乏评估此类干预措施对西方国家的影响的严格数据。在没有临床试验的情况下，建模提供了一种独特的方法来评估各种筛查和监视干预措施的潜在影响。在本文中，我们概述了评估西方国家GC筛查和监测成本效益的建模研究。