Background

Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin.

Objective

We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression.

Results

Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition.

Conclusion

Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.

中文翻译：

---

城市颗粒物诱导角质形成细胞中EGR-1表达，这与牛皮癣的严重程度有关

背景

早期生长反应蛋白（Egr）-1是对细胞生长和免疫反应启动重要的转录因子。它在银屑病皮肤中显着上调。

客观的

我们评估了Egr-1在斑块状牛皮癣皮肤损伤中的差异表达及其与牛皮癣严重程度的相关性。我们还使用了正常角质形成细胞的体外方法来分析城市颗粒物是否影响Egr-1的表达。

结果

Egr-1在牛皮癣皮肤，特别是基底层中明显上调。其表达与牛皮癣的严重程度呈正相关（ρ  = 0.497，P  = 0.013）。在体外条件下，暴露于城市颗粒物的角化细胞中它也显着上调。

结论

表皮中Egr-1的表达上调表明它通过加速表皮细胞复制而在牛皮癣中起作用，这可能归因于城市颗粒物。