BackgroundPrevious literature has extensively investigated the brain activity during response inhibition in adults with addiction. Inconsistent results including both hyper- and hypo-activities in the fronto-parietal network (FPN) and the ventral attention network (VAN) have been found in adults with addictions, compared with healthy controls (HCs).MethodsVoxel-wise meta-analyses of abnormal task-evoked regional activity were conducted for adults with substance dependence (SD) and behavioral addiction during response inhibition tasks to solve previous inconsistencies. Twenty-three functional magnetic resonance imaging studies including 479 substance users, 38 individuals with behavioral addiction and 494 HCs were identified.ResultsCompared with HCs, all addictions showed hypo-activities in regions within FPN (inferior frontal gyrus and supramarginal gyrus) and VAN (inferior frontal gyrus, middle temporal gyrus, temporal pole and insula), and hyper-activities in the cerebellum during response inhibition. SD subgroup showed almost the same activity patterns, with an additional hypoactivation of the precentral gyrus, compared with HCs. Stronger activation of the cerebellum was associated with longer addiction duration for adults with SD. We could not conduct meta-analytic investigations into the behavioral addiction subgroup due to the small number of datasets.ConclusionThis meta-analysis revealed altered activation of FPN, VAN and the cerebellum in adults with addiction during response inhibition tasks using non-addiction-related stimuli. Although FPN and VAN showed lower activity, the cerebellum exhibited stronger activity. These results may help to understand the neural pathology of response inhibition in addiction.

中文翻译：

---

成瘾成人反应抑制期间神经活动的改变：体素荟萃分析

背景先前的文献已经广泛研究了成瘾成人在反应抑制期间的大脑活动。与健康对照组 (HCs) 相比，在成瘾的成年人中发现了包括额顶网络 (FPN) 和腹侧注意网络 (VAN) 的过度活动和活动不足在内的不一致结果。在反应抑制任务期间，对物质依赖 (SD) 和行为成瘾的成年人进行了异常任务诱发的区域活动，以解决先前的不一致问题。共鉴定出 23 项功能性磁共振成像研究，包括 479 名物质使用者、38 名行为成瘾者和 494 名 HC。 结果与 HC 相比，所有成瘾都表现出 FPN（额下回和缘上回）和 VAN（额下回、颞中回、颞极和岛叶）区域的低活动性，以及反应抑制期间小脑的过度活动。与 HC 相比，SD 亚组表现出几乎相同的活动模式，中央前回的额外低激活。对于患有 SD 的成年人来说，更强的小脑激活与更长的成瘾持续时间有关。由于数据集数量少，我们无法对行为成瘾亚组进行荟萃分析调查。结论这项荟萃分析揭示了在使用非成瘾相关刺激的反应抑制任务期间成瘾成人的 FPN、VAN 和小脑的激活改变. 尽管 FPN 和 VAN 显示出较低的活性，小脑表现出更强的活动。这些结果可能有助于理解成瘾反应抑制的神经病理学。